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4-甲氧基肉桂酸

4-甲氧基肉桂酸用途

4-Methoxycinnamic acid 是一种天然苯丙烷类化合物。

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4-甲氧基肉桂酸名称

[ CAS 号 ]:
830-09-1

[ 中文名 ]:
4-甲氧基肉桂酸

[ 英文名 ]:
4-Methoxycinnamic acid

[中文别名 ]:

[英文别名 ]:

3-(4-Methoxy-phenyl)-acrylic acid
trans-4-Methoxycinnamic acid
4-MeOC6H4CH=CHCOOH
4-methoxycinnamate
RARECHEM BK HC T257
2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-
2-Propenoic acid, 3- (4-methoxyphenyl)-
(E)-3-(4-methoxyphenyl)acrylic acid
4-Methoxy-(2E)-cinnamic acid
4-Methoxyciamic acid

4-甲氧基肉桂酸生物活性

[ 描述 ]:

4-Methoxycinnamic acid 是一种天然苯丙烷类化合物。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

4-甲氧基肉桂酸是一种不常见的苯丙烷类化合物,参与Anigozanthos preissii的苯基苯丙酮生物合成[1]。

[参考文献]

[1]. Hidalgo W, et al. 4-Methoxycinnamic acid--An unusual phenylpropanoid involved in phenylphenalenone biosynthesis in Anigozanthos preissii. Phytochemistry. 2015 Sep;117:476-81.

[相关活性小分子]

4-甲氧基肉桂酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
342.6±17.0 °C at 760 mmHg

[ 熔点 ]:
173.5 °C(lit.)

[ 分子式 ]:
C₁₀H₁₀O₃

[ 分子量 ]:
178.185

[ 闪点 ]:
138.6±14.4 °C

[ 精确质量 ]:
178.062988

[ PSA ]:
46.53000

[ LogP ]:
2.36

[ 外观性状 ]:
白色,非晶形的粒状粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
Refrigerator

4-甲氧基肉桂酸MSDS

4-甲氧基肉桂酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD3391300

CHEMICAL NAME :: 2-Propenoic acid, 3-(4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 830-09-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H10-O3

MOLECULAR WEIGHT :: 178.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1300 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

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4-甲氧基肉桂酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UD3391300

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4-甲氧基肉桂酸文献

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.

Bioorg. Med. Chem. Lett. 15 , 1949-53, (2005)

1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 micr...

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...

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