菲尼酮

菲尼酮用途

Phenidone 是一种具有口服活性的,环氧化酶 (COX) 和脂氧合酶 (LOX) 的双重抑制剂,可以改善实验性自身免疫性脑脊髓炎大鼠的瘫痪。Phenidone 是一种对自发性高血压大鼠有效的降压剂。Phenidone 用作照片显像剂。

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菲尼酮名称

[ CAS 号 ]:
92-43-3

[ 中文名 ]:
菲尼酮

[ 英文名 ]:
Phenidone

[中文别名 ]:

[英文别名 ]:

1-Phenyl-3-pyrazolidinone
PYRAZOLIDONE A
1-Phenyl-3-oxopyrazolidine
Fenidon
1-phenylpyrazolidin-3-one
1-hydro-2-phenyl-pyrazol-5-one
phenitone
N-phenylpyrazolidin-3-one
1-P-3-P
1H-pyrazol-3-ol, 4,5-dihydro-1-phenyl-

菲尼酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[ 靶点 ]

COX

LOX

[体外研究]

菲尼酮显著抑制实验性自身免疫性脑脊髓炎(EAE)大鼠脊髓中COX-1/-2和5-LOX的增加[1]。

[体内研究]

非尼酮抑制AII依赖性肾血管性高血压大鼠血管脂氧合酶产物的形成并降低血压[2]。

[参考文献]

[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210.

[2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58.

[3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.

菲尼酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
304.1±25.0 °C at 760 mmHg

[ 熔点 ]:
119-121 °C(lit.)

[ 分子式 ]:
C₉H₁₀N₂O

[ 分子量 ]:
162.189

[ 闪点 ]:
137.7±23.2 °C

[ 精确质量 ]:
162.079315

[ PSA ]:
32.34000

[ LogP ]:
0.20

[ 外观性状 ]:
淡米色粉末或晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.620

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 稳定性 ]:
Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases.

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

菲尼酮MSDS

菲尼酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8750000

CHEMICAL NAME :: 3-Pyrazolidinone, 1-phenyl-

CAS REGISTRY NUMBER :: 92-43-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H10-N2-O

MOLECULAR WEIGHT :: 162.21

WISWESSER LINE NOTATION :: T5NMVTJ AR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 287 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 986 mg/kg/61D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0749 No. of Facilities: 1437 (estimated) No. of Industries: 14 No. of Occupations: 7 No. of Employees: 6865 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0749 No. of Facilities: 4414 (estimated) No. of Industries: 34 No. of Occupations: 37 No. of Employees: 51775 (estimated) No. of Female Employees: 25903 (estimated)

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菲尼酮安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H411

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R51/53

[ 安全声明 (欧洲) ]:
S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
UQ8750000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933199090

菲尼酮合成路线

菲尼酮上下游产品

菲尼酮上游产品

菲尼酮下游产品

菲尼酮海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

菲尼酮文献

Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum.

Nat. Prod. Commun. 10 , 2005-8, (2016)

The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC-MS analysis of the essential oil resulted ...

Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures.

Neurosci. Lett. 272(2) , 91-4, (1999)

The abrupt elevation in the levels of cyclooxygenase or lipoxygenase metabolites of arachidonic acid during cerebral ischemia contributes to neuronal injury. Recently, evidence has accumulated that bo...

The role of jasmonates in floral nectar secretion.

PLoS ONE 5(2) , e9265, (2010)

Plants produce nectar in their flowers as a reward for their pollinators and most of our crops depend on insect pollination, but little is known on the physiological control of nectar secretion. Jasmo...

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菲尼酮