藜芦酸
藜芦酸用途
用作医药中间体
藜芦酸名称
[ CAS 号 ]:
93-07-2
[ 中文名 ]:
3,4-二甲氧基苯甲酸
[ 英文名 ]:
Veratric acid
[中文别名 ]:
[英文别名 ]:
- MFCD00002500
- EINECS 202-215-7
- Benzoic acid, 3,4-dimethoxy-
- 3,4-Dimethoxybenzoic acid
- Veratric acid
藜芦酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
COX-2[3]
[体外研究]
[体内研究]
[参考文献]
[相关活性小分子]
藜芦酸物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
302.9±22.0 °C at 760 mmHg
[ 熔点 ]:
179-182 °C(lit.)
[ 分子式 ]:
C9H10O4
[ 分子量 ]:
182.173
[ 闪点 ]:
120.9±15.8 °C
[ 精确质量 ]:
182.057907
[ PSA ]:
55.76000
[ LogP ]:
1.99
[ 外观性状 ]:
透明淡棕色液体
[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C
[ 折射率 ]:
1.533
[ 储存条件 ]:
Refrigerator
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
slightly soluble
藜芦酸MSDS
藜芦酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DG8598750
- CHEMICAL NAME :
- Benzoic acid, 3,4-dimethoxy-
- CAS REGISTRY NUMBER :
- 93-07-2
- BEILSTEIN REFERENCE NO. :
- 0518285
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H10-O4
- MOLECULAR WEIGHT :
- 182.19
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980
藜芦酸安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36-S37/39
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
DG8598750
[ 海关编码 ]:
2918990090
藜芦酸合成路线
藜芦酸上下游产品
藜芦酸上游产品
藜芦酸下游产品
藜芦酸海关
[ 海关编码 ]: 2918990090
[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸(包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
藜芦酸文献
PLoS ONE 9(6) , e98581, (2014)
The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study ...
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorg. Med. Chem. 19 , 1381-9, (2011)
Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with t...
The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells.Cell. Immunol. 280(2) , 164-70, (2012)
Veratric acid, a simple benzoic acid derived from plants and fruits, has been reported to have anti-oxidant, anti-inflammation, and blood pressure-lowering effects. This study was designed to evaluate...
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产品详情:3,4-二甲氧基苯甲酸
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产品详情:[Perfemiker]3,4-二甲氧基苯甲酸,99%
公司名:上海阿拉丁生化科技股份有限公司
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产品详情:藜芦酸(3,4-二甲氧基苯甲酸)
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相关化合物
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