KY02111

产品详情：

更新时间： 2024-10-10 08:46:36

CAS号：1118807-13-8

常用名： N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺

价格：
￥需询单/1kg ￥需询单/1g ￥需询单/1mg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.IC50 value: Target: Wnt signaling inhibitorKY02111 Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.KY02111 (10 μM) increases the ratio of beating cardiac colonies as much as 70%-94% in cell aggregates of two hESC lines (KhES-1 and KhES-3), four hiPSC lines (253G1, IMR90-1, IMR90-4, and RCHIPC0003), and a mouse ESC line (R1). KY02111 (10 μM) results in 73%-85% postive IMR90-1 hiPSCs expressing the cardiac markers, cardiac troponin T (cTnT), αActinin, or NKX2.5, whereas only a few DMSO-treated cells are positive for the markers. KY02111 (10 μM) results in 16% postive IMR90-1 hiPSCs expressing the cardiac pacemaker marker, HCN4, whereas the ratio of Vimentin-positive cells (fibroblasts) decreases 3.3-fold. KY02111-induced cardiomyocytes (KY-CMs) expresses the cardiac markers, αMHC, NKH2.5, and HCN4, and that all of the ion channel genes examined are expressed at levels similar to those of adult heart tissue. KY02111 (10 μM) downregulates the expression of 72.7% target genes of canonical WNT signaling in IMR90-1 hiPSCs, suggesting that KY02111 inhibits canonical WNT signaling in hPSCs. KY02111 (10 μM) clearly reduces luciferase activities in both IMR90-1 hiPSCs and HEK293 cells in a dose-dependent manner in the TOPflash assay. KY02111 (10 μM-25 μM) increases cardiac differentiation about 80-fold in transgenic monkey ESCs compared to the control and does not show toxicity to cells even at high concentration. KY02111 (10 μM) significantly reduces luciferase activity in the TOPflash assay in SW480 cells, whereas XAV939 and IWP-2 does not. KY02111 (10 μM) dramatically reduces luciferase activity induced by GSK3β inhibitor BIO in SW480 cells, compared to that of XAV939 and IWP-2. KY02111 alone produces approximately 80% cTnT-positive cells, KY02111 in combination with other WNT inhibitors does not significantly increase differentiation efficiency, which shows that KY02111 effectively produces a high proportion of functional cardiomyocytes from hPSCs [1]. 物理化学性质： CAS号：1118807-13-8 常用中文名：N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺常用英文名：KY02111 分子式：C18H17ClN2O3S 分子量：376.857 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8°C

供应商信息：

公司名：上海楼岚生物科技有限公司

认证状态： 未认证供应商

商品数： 2474件

电话： 52996696

地址： 沪南路2729弄1310号

地区： 上海市浦东新区

联系人： 孙先生

联系人电话： 021-52996696

邮件：sales@lollanechem.com

网址：http://www.bioll.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-07-15 价格：需询单 N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺

2019-03-05 价格：￥708.0 N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺

2022-11-29 价格：￥需询单 KY02111

2020-12-08 价格：￥750.0 N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺

2025-09-17 价格：￥需询单 N-(6-氯苯并[d]噻唑-2-基)-3-(3,4-二甲氧基苯基)丙酰胺

2022-02-19 价格：￥529.9 KY02111

2023-03-21 价格：￥需询单 KY02111

查看所有价格请点击：

N-(6-氯-2-苯并噻唑)-3,4-二甲氧基苯丙酰胺价格

KY02111

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：