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盐酸鲁氟沙星(MF-934)

盐酸鲁氟沙星(MF-934)用途

Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种喹诺酮类抗菌剂,作用于人单核细胞,抑制B细胞分化, 且制剂拓扑异构酶抑。

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盐酸鲁氟沙星(MF-934)名称

[ CAS 号 ]:
106017-08-7

[ 中文名 ]:
盐酸芦氟沙星

[ 英文名 ]:
Rufloxacin (hydrochloride)

[中文别名 ]:

[英文别名 ]:

MF-934
MFCD00912283
Rufloxacin (hydrochloride)

盐酸鲁氟沙星(MF-934)生物活性

[ 描述 ]:

Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种喹诺酮类抗菌剂,作用于人单核细胞,抑制B细胞分化, 且制剂拓扑异构酶抑。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

盐酸鲁氟沙星(MF-934)物理化学性质

[ 沸点 ]:
574.6ºC at 760mmHg

[ 熔点 ]:
322-324ºC

[ 分子式 ]:
C₁₇H₁₉ClFN₃O₃S

[ 分子量 ]:
399.86700

[ 闪点 ]:
301.3ºC

[ 精确质量 ]:
399.08200

[ PSA ]:
91.08000

[ LogP ]:
2.50120

[ 储存条件 ]:
2-8℃

盐酸鲁氟沙星(MF-934)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8174500

CHEMICAL NAME :: 7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-10-(4-methyl-1- piperazinyl)-7-oxo-, monohydrochloride

CAS REGISTRY NUMBER :: 106017-08-7

LAST UPDATED :: 198709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H18-F-N3-O3-S.Cl-H

MOLECULAR WEIGHT :: 399.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 501 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 224 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

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盐酸鲁氟沙星(MF-934)安全信息

[ 海关编码 ]:
2942000000

盐酸鲁氟沙星(MF-934)合成路线

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盐酸鲁氟沙星(MF-934)下游产品

盐酸鲁氟沙星(MF-934)海关

[ 海关编码 ]: 2942000000