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苯甲酸苄酯

苯甲酸苄酯用途

Benzyl benzoate用于治疗小儿疥疮。

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苯甲酸苄酯名称

[ CAS 号 ]:
120-51-4

[ 中文名 ]:
苯甲酸苄酯

[ 英文名 ]:
benzyl benzoate

[中文别名 ]:

[英文别名 ]:

Scobenol
Benzyl benzoate
Scabitox
Scabide
Scabagen
EINECS 204-402-9
Benylate
benzoic acid benzyl ester
Zylate
benzoic acid, benzyl ester

苯甲酸苄酯生物活性

[ 描述 ]:

Benzyl benzoate用于治疗小儿疥疮。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 感染

[相关活性小分子]

苯甲酸苄酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
324.1±11.0 °C at 760 mmHg

[ 熔点 ]:
18 °C

[ 分子式 ]:
C₁₄H₁₂O₂

[ 分子量 ]:
212.244

[ 闪点 ]:
147.8±0.0 °C

[ 精确质量 ]:
212.083725

[ PSA ]:
26.30000

[ LogP ]:
3.97

[ 外观性状 ]:
无色油性液体带有令人愉快的芳香气味

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
通风低温干燥,与氧化剂存放

[ 稳定性 ]:
Stable. Substances to be avoided include strong oxidizing agents. Combustible.

[ 水溶解性 ]:
practically insoluble

苯甲酸苄酯MSDS

苯甲酸苄酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG4200000

CHEMICAL NAME :: Benzoic acid, benzyl ester

CAS REGISTRY NUMBER :: 120-51-4

BEILSTEIN REFERENCE NO. :: 2049280

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C14-H12-O2

MOLECULAR WEIGHT :: 212.26

WISWESSER LINE NOTATION :: RVO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1897,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >22440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 84,358,1945

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2240 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 84,358,1945

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1015,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1015,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 180 mL/kg/13W-I

TOXIC EFFECTS :: Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 11590 No. of Facilities: 264 (estimated) No. of Industries: 7 No. of Occupations: 38 No. of Employees: 11292 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 11590 No. of Facilities: 5972 (estimated) No. of Industries: 28 No. of Occupations: 50 No. of Employees: 83538 (estimated) No. of Female Employees: 44948 (estimated)

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苯甲酸苄酯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H411

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S25

[ 危险品运输编码 ]:
UN 3082 9 / PGIII

[ WGK德国 ]:
2

[ RTECS号 ]:
DG4200000

[ 海关编码 ]:
4002191900

苯甲酸苄酯合成路线

苯甲酸苄酯上下游产品

苯甲酸苄酯上游产品

苯甲酸苄酯下游产品

苯甲酸苄酯制备

1.目前香料工业中采用醇交换法生产苯甲酸苄酯。由苯甲酸乙酯和苯甲醇进行醇交换。

2.由苯甲酸乙酯与苯甲醇进行酯交换反应，经水洗、分层、干燥、蒸馏得产品。或者由苯甲醛缩合制得。

精制方法：常含有游离的酸和醇等杂质。精制时用碳酸氢钠或碳酸钠洗涤，无水碳酸钾或硫酸钠干燥后蒸馏。

3.过程反应式为：

在三口烧瓶中加入氢氧化钠和水，溶解后再加苯甲酸，加热溶解后，滴加氯化苄，在106℃回流4H。稍冷，分出酯层，水洗、碱洗，然后减压蒸馏，即得成品。

4. 用氧化镁做为催化剂，用苄醇与苯甲酸甲酯在200℃左右进行酯交换反应制取。

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苯甲酸苄酯海关

[ 海关编码 ]: 2916310090

[ 中文概述 ]:
2916310090 其他苯甲酸及其盐和酯. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916310090 other benzoic acid and its salts and esters。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

苯甲酸苄酯文献

Plug-n-play microfluidic systems from flexible assembly of glass-based flow-control modules.

Lab Chip 15(8) , 1869-78, (2015)

In this study, we report on a simple and versatile plug-n-play microfluidic system that is fabricated from flexible assembly of glass-based flow-control modules for flexibly manipulating flows for ver...

Cost-benefit analysis of ivermectin, permethrin and benzyl benzoate in the management of infantile and childhood scabies.

Expert Opin. Pharmacother. 4(9) , 1521-4, (2003)

In the US, 6% sulfur in petrolatum has been the most frequently administered treatment for infantile scabies. It appears to be safe but there is no literature containing a large series of patients on ...

Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.

ChemMedChem 10(4) , 736-41, (2015)

Numerous small organic compounds exist in equilibrium among monomers, soluble oligomers, and insoluble aggregates in aqueous solution. Compound aggregation is a major reason for false positives in dru...

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苯甲酸苄酯

苯甲酸苄酯用途

苯甲酸苄酯名称

苯甲酸苄酯生物活性

苯甲酸苄酯物理化学性质

苯甲酸苄酯MSDS

详细MSDS(安全技术说明书)

苯甲酸苄酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

苯甲酸苄酯安全信息

苯甲酸苄酯合成路线

详细合成路线

苯甲酸苄酯上下游产品

苯甲酸苄酯上游产品

苯甲酸苄酯下游产品

苯甲酸苄酯制备

苯甲酸苄酯海关

苯甲酸苄酯文献

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