< 生产厂家价格 >

甘露醇

甘露醇用途

D-Mannitol是渗透性利尿剂,具有较弱的肾脏血管扩张活性。

点击显示

甘露醇名称

[ CAS 号 ]:
69-65-8

[ 中文名 ]:
甘露醇

[ 英文名 ]:
D-Mannitol

[中文别名 ]:

[英文别名 ]:

Mannit p
MFCD00064287
Cytosine API
4-aminopyrimidin-2-one
D-Mannitol
EINECS 200-711-8
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Mannitol
Cordycepate
(2R,3R,4R,5R)-Hexan-1,2,3,4,5,6-hexol

甘露醇生物活性

[ 描述 ]:

D-Mannitol是渗透性利尿剂,具有较弱的肾脏血管扩张活性。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.

[2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.

[3]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.

[相关活性小分子]

甘露醇物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
494.9±0.0 °C at 760 mmHg

[ 熔点 ]:
167-170ºC

[ 分子式 ]:
C₆H₁₄O₆

[ 分子量 ]:
182.172

[ 闪点 ]:
292.5±23.3 °C

[ 精确质量 ]:
182.079041

[ PSA ]:
121.38000

[ LogP ]:
-4.67

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.597

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：可溶；不溶：乙醚

甘露醇MSDS

甘露醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OP2060000

CHEMICAL NAME :: Mannitol, D-

CAS REGISTRY NUMBER :: 69-65-8

BEILSTEIN REFERENCE NO. :: 1721898

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H14-O6

MOLECULAR WEIGHT :: 182.20

WISWESSER LINE NOTATION :: Q1YQYQ 2 -BBAA -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 17143 mg/kg/2D-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4308 No. of Facilities: 1555 (estimated) No. of Industries: 14 No. of Occupations: 31 No. of Employees: 41268 (estimated) No. of Female Employees: 28689 (estimated)

点击显示

甘露醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
OP2060000

[ 海关编码 ]:
2905430000

甘露醇合成路线

甘露醇上下游产品

甘露醇上游产品

甘露醇下游产品

甘露醇制备

1.甘露醇可从海带中提取，也可以从海藻中提取，但较多采用葡萄糖或蔗糖溶液电解还原或催化还原的方法。下面分别简单介绍。
（1）从海带中提取的方法　将干海带加适量水常温浸泡使其溶胀后不断搅拌使甘露醇溶入水中。将洗水液用烧碱调PH值为12以上，使其沉淀16H以上。再用1∶1的硫酸调PH值为中性后蒸发浓缩至相对密度为1.30～1.32时冷却，上层清液再蒸发浓缩至相对密度为1.42～1.45时，趋热离心除盐，浓缩液冷却结晶，离心分离得甘露醇粗品。将粗品用沸水重结晶，活性炭脱色、醇洗脱氯离子、干燥等操作得纯品甘露醇。
（2）电解还原法　以葡萄糖或蔗糖为原料，配成适宜浓度的溶液后，用硫酸钠调整PH值为7.0后加入电解槽进行电解。电解液经活性炭脱色、真空浓缩、乙醇脱盐、冷却结晶、离心等操作后得粗品甘露醇。粗品甘露醇再经重结晶后得精品。
（3）催化还原法　催化还原法是将蔗糖溶液经水解、中和、催化加氢等操作制得山梨糖醇和甘露糖醇粗品溶液，再经过滤、活性炭脱色、离子交换、浓缩、结晶、分离等操作得甘露醇精品。

2.米曲霉菌发酵法

3.还原法　蔗糖水解生成的葡萄糖和果糖再还原生成山梨糖醇和甘露糖醇的混合物，再经脱色、分离和纯化得甘露糖醇。

点击显示

甘露醇海关

[ 海关编码 ]: 2905430000

[ 中文概述 ]:
HS:2905430000 甘露糖醇增值税率:17.0% 退税率:9.0% 监管条件:AB 最低关税:8.0% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS:2905430000 (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:8.0% General tariff:30.0%

甘露醇文献

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury.

Biochim. Biophys. Acta 1837(10) , 1790-800, (2014)

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tu...

Rapid detection of sugar alcohol precursors and corresponding nitrate ester explosives using direct analysis in real time mass spectrometry.

Analyst 140(8) , 2785-96, (2015)

This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstr...

更多文献

甘露醇

甘露醇用途

甘露醇名称

甘露醇生物活性

甘露醇物理化学性质

甘露醇MSDS

详细MSDS(安全技术说明书)

甘露醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

甘露醇安全信息

甘露醇合成路线

详细合成路线

甘露醇上下游产品

甘露醇上游产品

甘露醇下游产品

甘露醇制备

甘露醇海关

甘露醇文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物