<生产厂家价格>

磺胺吡啶

磺胺吡啶用途

【用途一】
医药中间体。

磺胺吡啶名称

[ CAS 号 ]:
144-83-2

[ 中文名 ]:
磺胺吡啶

[ 英文名 ]:
Sulfapyridine

[中文别名 ]:

[英文别名 ]:

N'-2-Pyridylsulfanilide
Sulfapyridine (USP)
2-(4-Aminobenzenesulfonamido)pyridine
4-Amino-N-(2-pyridinyl)benzenesulfonamide
EINECS 205-642-7
MFCD00038036
Sulfapyridine
4-Amino-N-(pyridin-2-yl)benzenesulfonamide
M & B 693
T6NJ BMSWR DZ

磺胺吡啶生物活性

[ 描述 ]:

Sulfapyridine(Dagenan) 是磺胺类抗菌素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

天然产物 >> 生物碱

研究领域 >> 感染

[参考文献]

[1]. Hanauer, S.B., Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis. Aliment Pharmacol Ther, 2006. 24 Suppl 3: p. 37-40.

[相关活性小分子]

磺胺吡啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
473.5±51.0 °C at 760 mmHg

[ 熔点 ]:
191-193°C

[ 分子式 ]:
C₁₁H₁₁N₃O₂S

[ 分子量 ]:
249.289

[ 闪点 ]:
240.2±30.4 °C

[ 精确质量 ]:
249.057190

[ PSA ]:
93.46000

[ LogP ]:
0.03

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.674

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 22 ºC

磺胺吡啶MSDS

磺胺吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9625000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(2-pyridinyl)-

CAS REGISTRY NUMBER :: 144-83-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C11-H11-N3-O2-S

MOLECULAR WEIGHT :: 249.31

WISWESSER LINE NOTATION :: T6NJ BMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15800 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16600 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 8400 mg/kg/21D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - structural or functional changes in ureter Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13482 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10080 mg/kg

SEX/DURATION :: male 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12600 mg/kg

SEX/DURATION :: male 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4200 mg/kg

SEX/DURATION :: male 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 46200 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 1667 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 283,59,1992 *** REVIEWS *** TOXICOLOGY REVIEW JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ. Volume(issue)/page/year: 10,343,1943

磺胺吡啶安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DA9625000

[ 海关编码 ]:
2935009090

磺胺吡啶合成路线

磺胺吡啶上下游产品

磺胺吡啶上游产品

磺胺吡啶下游产品

磺胺吡啶制备

2-氨基吡啶经缩合、水解而得。

磺胺吡啶海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺吡啶文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1345 , 17-28, (2014)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

更多文献

磺胺吡啶相关知识

磺胺吡啶在兽医领域的使用情况？

2026-06-11 19:22:46

磺胺吡啶（CAS 144-83-2，分子式 C₁₁H₁₁N₃O₂S）属于磺胺类抗菌药物，其化学结构为4-氨基-N-吡啶-2-基苯磺酰胺。在兽医领域中，磺胺吡啶主要用于治疗由敏感细菌引起的全身性或局部感染，尤其与二氢叶酸还原酶抑制剂...

磺胺吡啶的化学结构与抗菌活性的关系？

2026-06-11 19:23:41

磺胺吡啶（CAS 144-83-2，化学名：4-氨基-N-吡啶-2-基苯磺酰胺）属于磺胺类抗菌药物，其化学结构由对氨基苯磺酰胺母核与2-吡啶基取代基构成。该分子的抗菌活性本质上源于磺胺核心对二氢叶酸合成酶（DHPS）的竞争性抑制，...

磺胺吡啶在临床上曾经用于哪些疾病？

2026-06-11 19:24:07

磺胺吡啶（Sulfapyridine），CAS号144-83-2，化学名称为4-氨基-N-(吡啶-2-基)苯磺酰胺，分子式为C₁₁H₁₁N₃O₂S，分子量249.29 g/mol。其结构由对氨基苯磺酰胺核心与2-氨基吡啶基团通过磺...

磺胺吡啶在光照下是否容易分解？

2026-06-11 19:24:30

磺胺吡啶（Sulfapyridine，CAS 144-83-2，分子式 C₁₁H₁₁N₃O₂S）属于第一代磺胺类抗菌药物，其化学结构中包含对氨基苯磺酰胺母核及吡啶环侧链。该化合物在临床和实验室中常以固体粉末或溶液形式使用，但其对光...

磺胺吡啶在临床上曾经用于哪些疾病？

2026-06-11 19:24:32

磺胺吡啶的氧化稳定性如何？

2026-06-11 19:24:58

磺胺吡啶（分子式：C₁₁H₁₁N₃O₂S，CAS号：144-83-2）的氧化稳定性由其分子内电子分布和官能团排列决定。该分子由对氨基苯磺酰胺骨架与2-吡啶基取代基构成，其中磺酰胺基（-SO₂NH-）连接苯环与吡啶环。关键氧化敏感位...

磺胺吡啶的代谢途径和产物是什么？

2026-06-11 19:26:37

1 代谢途径概览

磺胺吡啶（Sulfapyridine，CAS 144-83-2，分子式 C₁₁H₁₁N₃O₂S）为磺胺类抗菌药物，其体内...

磺胺吡啶与其他药物存在哪些相互作用？

2026-06-11 19:27:06

磺胺吡啶（化学式：C₁₁H₁₁N₃O₂S，分子量：261.30 g/mol，结构式：4-氨基-N-(2-吡啶基)苯磺酰胺）属于磺胺类抗菌药物，其核心药效基团为对氨基苯磺酰胺结构。该药物通过竞争性抑制细菌的二氢叶酸合成酶，阻断对氨基...

磺胺吡啶的检测方法有哪些？

2026-06-11 19:27:32

磺胺吡啶（4-氨基-N-2-吡啶基苯磺酰胺，C₁₁H₁₁N₃O₂S）属于磺胺类抗菌药物，其分子中含有的苯胺基团（-NH₂）、磺酰胺基团（-SO₂NH-）以及吡啶杂环赋予其特定的紫外吸收特性、电化学活性及衍生化反应能力。检测方法的设...

磺胺吡啶的合成方法有哪些？

2026-06-11 19:27:48

磺胺吡啶（CAS 144-83-2），化学名为4-氨基-N-(吡啶-2-基)苯磺酰胺，分子式为C₁₁H₁₁N₃O₂S，相对分子质量249.29。该化合物属于磺胺类抗菌药物，其结构中包含对氨基苯磺酰胺母核和2-吡啶基取代基，磺酰胺基...

磺胺吡啶的吸湿性如何？

2026-06-11 19:29:13

磺胺吡啶（Sulfapyridine，CAS 144-83-2，分子式 C₁₁H₁₁N₃O₂S）作为第一代磺胺类抗菌药物，其化学稳定性直接关系到药品生产、制剂加工及临床使用的可靠性。吸湿性是影响固体药物物理化学性质的关键参数，包括...

磺胺吡啶的主要作用机制是什么？

2026-06-11 19:29:27

一、化学结构与靶点识别基础

磺胺吡啶（Sulfapyridine，分子式 C₁₁H₁₁N₃O₂S）属于磺胺类抗菌药物家族，其核心结构为对氨...

磺胺吡啶在不同溶剂中的溶解度差异？

2026-06-11 19:29:52

磺胺吡啶（C₁₁H₁₁N₃O₂S，4-氨基-N-(2-吡啶基)苯磺酰胺）分子由苯环、磺酰胺基（-SO₂NH-）、氨基（-NH₂）和吡啶环组成。该分子同时具备酸性基团（磺酰胺基上的N-H，pKa ~8.5）和碱性基团（吡啶环上的氮原...

磺胺吡啶的酸碱稳定性怎样？

2026-06-11 20:48:58

磺胺吡啶（CAS 144-83-2，分子式 C₁₁H₁₁N₃O₂S）是一种典型的磺胺类药物，结构中同时含有芳香伯胺、磺酰胺基团以及吡啶环。在化学工业与实验室应用中，磺胺吡啶常作为原料药、分析标准品或合成中间体，其酸碱稳定性直接决定...

磺胺吡啶是否容易产生耐药性？

2026-06-11 21:21:55

磺胺吡啶（C₁₁H₁₁N₃O₂S，CAS 144-83-2）属于磺胺类抗生素，其抗菌活性依赖于对细菌二氢叶酸合成酶（dihydropteroate synthase，DHPS）的竞争性抑制。该酶催化对氨基苯甲酸（pABA）与二氢蝶...

磺胺吡啶的毒性等级和安全性数据？

2026-07-10 14:14:51

磺胺吡啶（Sulfapyridine，CAS 144-83-2）是一种磺胺类抗菌药物，分子式为 C₁₁H₁₁N₃O₂S，分子量 249.29 g/mol。其结构包含一个对氨基苯磺酰胺母核，吡啶环取代于磺酰胺基末端。该化合物在历史上...

磺胺吡啶的常见副作用有哪些？

2026-07-30 20:40:33

1 磺胺吡啶的结构与作用基础

磺胺吡啶的化学名为4-氨基-N-2-吡啶基苯磺酰胺，分子式为C₁₁H₁₁N₃O₂S，分子量为261.30 g...