三氯生

三氯生用途

【用途一】
用于高档日化产品的生产，医疗、饮食行业器械消毒剂、织物抗菌防臭整理剂的配制等
【用途二】
防腐剂和防霉剂，用于化妆品，乳剂和树脂，也用来制造消毒药皂。该品小鼠口服LD50为4g/kg。
【用途三】
三氯生(Irgasan)是一种广谱抗菌剂，它抑制细菌和疟原虫中II型脂肪酸合成酶(FAS-II)，也抑制哺乳动物脂肪酸合成酶(FASN), 而且可能还具有抗癌活性。

三氯生名称

[ CAS 号 ]:
3380-34-5

[ 中文名 ]:
三氯生

[ 英文名 ]:
Triclosan

[中文别名 ]:

[英文别名 ]:

TRICHLOSAN
IRGASAN
Irgacare MP
ch3565
Cloxifenol
ZilesanUW.
2,4,4'-trichloro-2'-hydroxydiphenyl ether
TROX-100
irgasandp300
TRICLOSAN USP

三氯生生物活性

[ 描述 ]:

Triclosan是一种在消费类产品中发现的抗菌剂和抗真菌剂,包括肥皂, 洗涤剂, 玩具, 和手术清洗用品。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[相关活性小分子]

三氯生物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
344.6±42.0 °C at 760 mmHg

[ 熔点 ]:
56-60 °C(lit.)

[ 分子式 ]:
C₁₂H₇Cl₃O₂

[ 分子量 ]:
289.542

[ 闪点 ]:
162.2±27.9 °C

[ 精确质量 ]:
287.951172

[ PSA ]:
29.46000

[ LogP ]:
5.17

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：10 mg/l 25 °C；可溶于：甲醇

三氯生MSDS

三氯生毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KO1100000

CHEMICAL NAME :: Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl

CAS REGISTRY NUMBER :: 3380-34-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C12-H7-Cl3-O2

MOLECULAR WEIGHT :: 289.54

WISWESSER LINE NOTATION :: QR CG FOR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4400 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 5 mg/disc

REFERENCE :: JOSCDQ Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 1976- Volume(issue)/page/year: 15,243,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1355 No. of Facilities: 1242 (estimated) No. of Industries: 18 No. of Occupations: 55 No. of Employees: 73886 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1355 No. of Facilities: 4403 (estimated) No. of Industries: 33 No. of Occupations: 52 No. of Employees: 188670 (estimated) No. of Female Employees: 121892 (estimated)

三氯生安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H410

[ 警示性声明 ]:
P273-P305 + P351 + P338-P391-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi,N

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S39-S46-S60-S61-S24/25-S22

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
KO1100000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2909500000

三氯生合成路线

三氯生上下游产品

三氯生上游产品

三氯生下游产品

三氯生制备

1.合成2, 4, 4 ′ - 三氯 - 2 ′ - 羟基二苯醚( 三氯新) 。将2, 4, 4 ′ - 三氯 - 2 ′ - 氨基二苯醚( TAD E) 与亚硝酸、硫酸及二氯苯混合、加热,得到重氮盐溶液,水解后再加入碱液进行反应,生成三氯新的钠盐和多种杂质的沉淀,弃去沉淀,用有机溶剂提取三氯新数次,蒸馏后得到粗制三氯新,再用硫酸中和,萃取三氯新,弃去上层液,蒸馏下层萃取液,经高真空蒸馏后再在有机溶液中重结晶得到终产品三氯新。

三氯生海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

三氯生文献

Determination of plaque viability following a single brushing with commercial toothpastes.

J. Clin. Dent. 24(1) , 20-4, (2013)

The purpose of this study was to determine the viability of dental plaque at 12 hours following brushing with Colgate Great Regular Flavor (0.83% MFP), Crest Pro-Health (0.454% SnF), and Colgate Total...

Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: an in vitro study.

Aust. Dent. J. 60 , 368-74, (2015)

Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices ...

RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.

Antimicrob. Agents Chemother. 52 , 3604-11, (2008)

Salmonella enterica serovar Typhimurium SL1344, in which efflux pump genes (acrB, acrD, acrF, tolC) or regulatory genes thereof (marA, soxS, ramA) were inactivated, was grown in the presence of 240 an...

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三氯生