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紫铆因

紫铆因用途

Butein是植物多酚,作为一个特定的蛋白质酪氨酸激酶抑制剂。

紫铆因名称

[ CAS 号 ]:
487-52-5

[ 中文名 ]:
紫铆因

[ 英文名 ]:
Butein

[中文别名 ]:

[英文别名 ]:

Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI)
MFCD00017300
Einecs 207-659-5
Butein,2',3,4,4'-Tetrahydroxychalcone
Butein
2',3,4,4'-TETRAHYDROCHALCONE
3,4,2',4'-TETRAHYDROXYCHALCONE
QR CQ DV1U1R CQ DQ &&E Form
2',3,4,4'-TETRAHYDROXYCHALCONE
2′,3,4,4′-Tetrahydroxychalcone

紫铆因生物活性

[ 描述 ]:

Butein是植物多酚,作为一个特定的蛋白质酪氨酸激酶抑制剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 酚类

研究领域 >> 癌症

[ 靶点 ]

EGFR

[参考文献]

[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8.

[2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66

[3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122.

[4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.

[相关活性小分子]

紫铆因物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
560.9±50.0 °C at 760 mmHg

[ 熔点 ]:
216°C

[ 分子式 ]:
C₁₅H₁₂O₅

[ 分子量 ]:
272.25

[ 闪点 ]:
307.1±26.6 °C

[ PSA ]:
17.07000

[ LogP ]:
2.66

[ 外观性状 ]:
solid | yellow

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.748

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
DMSO: >50 mg/mL

紫铆因MSDS

详细MSDS(安全技术说明书)

紫铆因安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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紫铆因文献

Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.

Int. J. Mol. Med. 36 , 957-66, (2015)

Drug resistance remains a major challenge in cancer therapy. Butein, a polyphenolic compound, has been shown to exhibit anticancer activity through the inhibition of the activation of the protein kina...

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth.

Mol. Carcinog. 54(4) , 322-31, (2015)

Lung cancer is a leading cause of death worldwide and MET amplification is a major therapeutic limitation in acquired-resistance lung cancer. We hypothesized that butein, a phytochemical, can overcome...

Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway.

Curr. Eye Res. 37 , 730-739, (2012)

To study the cytotoxic effects and related signaling pathways of butein on human uveal melanoma cells in vitro.Three human uveal melanoma cell lines (M17, SP6.5, and C918), retinal pigment epithelial ...

更多文献

紫铆因相关知识

紫铆因的生物活性

2018-10-10 17:05:59

紫铆因是一种从漆树（Rhus verniciflua）分离的植物多酚，可抑制蛋白酪氨酸激酶和EGFR的活化。靶点为EGFR。紫铆因的生物活性详情如下：1. 体外活性：紫铆因抑制表皮生长因子（EGF）刺激HepG2细胞中EGF受体的自身磷酸酪氨酸水平，并抑制EGF受体和p60c-src的酪氨酸特...

紫铆因