107133-36-8

• 常用中文名：培哚普利
• 常用英文名：Perindopril erbumine
• CAS号：107133-36-8
• 分子式：C₂₃H₄₃N₃O₅
• 分子量：441.605
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-06-08 21:03:50
• 更新时间：2026-08-02 11:12:01
• Perindopril是长效血管紧张素转换酶(ACE)抑制剂。

名称

• 中文名: 培哚普利叔丁胺盐
• 英文名: perindopril erbumine
• 中文别名: 培哚普利叔丁胺; N-[(1S)-(1-乙氧羰基) -丁基]-L-丙氨酰-(2S,3AS,7AS)- 八氢吲哚-2-羧酸叔丁胺盐; 培哚; 培叔丁胺 标准品; 培哚普利叔丁氨盐; 阿莫西林克拉维酸钾4:1—化工; 大叶海藻提取物; 培哚普利叔丁胺盐杂质; 培峰鉴别 标准品; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(乙氧羰基)丁基]氨基]丙酰基]八氢-1H-吲哚-2-羧酸叔丁胺盐; (2S,3aS,7aS)-1-((S)-2-(((S)-乙氧基-1-氧代戊烷-2-基)氨基)丙酰基)八氢-1H-吲哚-2-羧酸叔丁胺盐; 阿莫西林钠克拉维酸钾5:1-化工; 培哚普利相关物质A 标准品; 2-甲基丙-2-胺(2S,3AS,7AS)-1-((S)-2-(((S)-乙氧基-1-氧代戊烷-2-基)氨基)丙酰基)八氢-1H-吲哚-2-羧酸盐; 甲磺酸培高利特杂质B; 培多普利; 培哚普利/用于立体异构杂质鉴定/A1A; 阿莫西林系列/微晶纤维素克拉维酸钾1:1; Perindopril Erbumine (Aceon) 1000mg试剂; 培哚普利T-丁胺; 水溶性鞣酸蛋白; 培吸普利叔丁胺; 培哚普利叔丁胺 Solbio/索莱宝 IP1550; 培哚普利叔丁胺盐(标准品); 培哚普利杂质T(叔丁胺盐); 培哚普利特丁胺盐; 培立体度 标准品; 培哚普利/ (2S,3AS,7AS)-1-[(2S)-2-[[(1S)-1-(乙氧羰基)丁基]氨基]丙酰基]八氢-1H-吲哚-2-羧酸叔丁胺盐; 2-甲基丙-2-胺(2S,3AS,7AS)-1-((S)-2-(((S)-1-乙氧基-1-氧戊烷-2-基)氨基)丙酰基)八氢-1H- 吲哚-2-羧酸盐 (培哚普利杂质); 培哚普利叔丁胺,10 MM DMSO 溶液; 培哚普利,培哚普利叔丁胺盐
• 英文别名: Perindopril erbumine salt; S 9490-3; PrestariuM; (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name); Perindopril Impurity T(tert-Butylamine); 1-[2-(1-Ethoxycbonylbutylamino)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-cboxylic acid 2-methyl-2-propanamine (1:1); Perindopril for peak identification (Y0000771); (6,9R,10-9-[(methylsulfonyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline (pergolide sulfone); Perinodpril ErbiMune; Perindopril t-ButylaMine; Perindopril erbumine //BP; Perindoril; Perindopril ErbumineQ: What is Perindopril Erbumine Q: What is the CAS Number of Perindopril Erbumine Q: What is the storage condition of Perindopril Erbumine; Perindopril for stereochemical purity CRS; (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1); Perindopril tert-butylamine CRS; Perindopril t-Butylamine Salt; Perindopril Related Compound A (20 mg) ((2S,3aS,7aS)-octahydro-1H-indole-2-cboxylic acid); (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1); Procaptan; Unii-1964X464oj; Coversyl; (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1); Perindopril erbumine, 10 mM in DMSO; (2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1); Perinodopril; PrestiuM; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-cboxylic Acid 2-Methyl-2-propanaMine; Coversum; Perindopril t-Butylamine; Perindopril Impurity CC; Water-soluble tannalbin; Perindopril for stereochemical purity (Y0000207); Aceon; 2-Methylpropan-2-amine (2S,3aS,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-cboxylate (Perindopril Impurity); (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-cboxylic acid tert-butylamine salt; Perindopril ErbuMine (Aceon); (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name); acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1); McN-A 2833-109; Perindopril Erbumine (S-9490-3); McN-A-2833-109; ButylaMiniperindopril; Perindopril Tables; Perindopril tert-butylamine salt; Perindopril Erbumine; CoversuM; Perindopril Impurity BB; Perindopril for peak identification CRS; MFCD02313824; Perindopril tert-butylamine; (2S,3aS,7aS)-1-[(2S)-2- {[(2S)-1-ethoxy-1-oxopentan-2- yl]amino}propanoyl]-octahydro-1H-indole-2- cboxylic acid 2-methylpropan-2-amine; Water-soluble tannic acid protein; prindopril API; PERINDOPRIL T-BUTYLAMINE SALT; 2-Methylpropan-2-amine (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycbonyl)butyl]amino]propanoyl]octahydro-1H-indole-2-cboxylate; S-9490-3; Perindopril t-butylamine salt - Bio-X; PERINDOPRIL TERT-BUTYLAMINE DRUG SUBSTANCE; Perindopril Impurity AA; (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1); 2-Methylpropan-2-amine (2S,3aS,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-cboxylate; 1H-Indole-2-cboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycbonyl)butyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,7aS)-, compd. with 2-methyl-2-propanamine (1:1); Pederindopril

物化性质

• 密度: 1.15 g/cm3
• 沸点: 537.4ºC at 760mmHg
• 熔点: 126-128ºC
• 分子式: C₂₃H₄₃N₃O₅
• 分子量: 441.605
• 闪点: 278.8ºC
• 精确质量: 441.320282
• PSA: 121.96000
• LogP: 3.71330
• 外观性状: 白色固体
• 储存条件: -20°C Freezer
• 水溶解性: H2O: soluble10mg/mL, clear

生物活性

• 描述: Perindopril是长效血管紧张素转换酶(ACE)抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.

  [2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: NL5999600

合成路线

82834-16-0 ~95% 107133-36-8

文献：Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2007/43103 A1, 2007 ; Location in patent: Page/Page column 2 ;

1159491-00-5 82834-12-6 75-64-9 ~62% 107133-36-8

文献：KRKA, tovarna zdravil, d.d., Novo mesto Patent: EP1792896 A1, 2007 ; Location in patent: Page/Page column 7-8 ;

75-64-9 ~91% 107133-36-8

文献：QUIMICA SINTETICA, S.A. Patent: WO2006/70276 A1, 2006 ; Location in patent: Page/Page column 8 ;

86647-57-6 82834-12-6 75-64-9 ~% 107133-36-8

文献：WO2006/137082 A1, ; Page/Page column 11-12 ;

82834-16-0 75-64-9 ~94% 107133-36-8

文献：Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2006/178421 A1, 2006 ; Location in patent: Page/Page column 2 ;

200423-22-9 869877-95-2 75-64-9 ~% 107133-36-8

文献：US2006/211867 A1, ; Page/Page column 4 ;

869877-95-2 80875-98-5 75-64-9 ~% 107133-36-8

文献：US2006/211867 A1, ; Page/Page column 3-4 ;

上下游产品

上游产品  6
82834-16-0 82834-12-6 75-64-9 86647-57-6
869877-95-2 80875-98-5
下游产品  3
95153-31-4 129970-98-5 82834-16-0