5-羟基-7,3',4'-三甲氧基黄酮

• 常用名: 5-羟基-7,3',4'-三甲氧基黄酮
• 英文名: 5-Hydroxy-3',4',7-trimethoxyflavone
• CAS号: 29080-58-8
• 分子量: 328.316
• 密度: 1.3±0.1 g/cm3
• 沸点: 536.3±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₆
• 熔点: N/A
• 闪点: 197.0±23.6 °C

5-羟基-7,3',4'-三甲氧基黄酮用途

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮,Lippia nodiflora L. 已被证明具有抗炎,解热,镇咳,抗糖尿病,抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子,如 TNF-α,IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。

5-羟基-7,3',4'-三甲氧基黄酮名称

• 中文名: 7,3',4'-三-O-甲基毛地黄黄酮
• 英文名: 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one

5-羟基-7,3',4'-三甲氧基黄酮生物活性

• 描述: 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮,Lippia nodiflora L. 已被证明具有抗炎,解热,镇咳,抗糖尿病,抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子,如 TNF-α,IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
  信号通路 >> 细胞凋亡 >> TNF受体
  研究领域 >> 代谢疾病
• 靶点实验:

  TNF-α

  IL-6

  IL-1β

• 参考文献:

  [1]. Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.

5-羟基-7,3',4'-三甲氧基黄酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 536.3±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₆
• 分子量: 328.316
• 闪点: 197.0±23.6 °C
• 精确质量: 328.094696
• PSA: 78.13000
• LogP: 3.22
• InChIKey: HIXDQWDOVZUNNA-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.606
• 储存条件: 2-8℃，干燥，密闭

5-羟基-7,3',4'-三甲氧基黄酮安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

5-羟基-7,3',4'-三甲氧基黄酮海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基-7,3',4'-三甲氧基黄酮靶点实验

查看更多实验

实验名称：Cytotoxicity against human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL987594

实验名称：Antioxidant activity assessed as ABTS free radical scavenging activity by spectrophot... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2410730

实验名称：Cytotoxicity against mouse P388 cells at 100 ug/mL 来源：ChEMBL 靶标：P388 External Id：CHEMBL987593

实验名称：Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL2410725

实验名称：Cell cycle arrest in human MCF7 cells assessed as reduction in S-phase accumulation a... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL2410724

实验名称：Cell cycle arrest in human MCF7 cells assessed as increase in G0/G1-phase accumulatio... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL2410723

实验名称：Cell cycle arrest in human MCF7 cells assessed as reduction in G2/M-phase accumulatio... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL2410722

实验名称：Immunostimulant activity in PHA-stimulated human PBL assessed as lymphocyte transform... 来源：ChEMBL 靶标：PBL External Id：CHEMBL2410729

实验名称：Kinase Assay from Article 10.1002/cbic.201000487: "Biological evaluation and structur... 来源：BindingDB 靶标：N/A External Id：BindingDB_5042_1

实验名称：Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL2410728

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5-羟基-7,3',4'-三甲氧基黄酮英文别名

• 2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one
• 5-Hydroxy-3',4',7-trimethoxyflavone
• luteolin-3'-4',7-trimethyl ether
• 5-hydroxy-7,2',6'-trimethoxyflavone
• 5-hydroxy-7,3',4'-trimethoxy-flavone
• Luteolin-7,3',4'-trimethylether
• 5-hydroxy-7,3',4'-trimethoxyflavone