alpha-菠菜甾醇

• 常用名: alpha-菠菜甾醇
• 英文名: alpha-Spinasterol
• CAS号: 481-18-5
• 分子量: 412.691
• 密度: 1.0±0.1 g/cm3
• 沸点: 500.0±44.0 °C at 760 mmHg
• 分子式: C₂₉H₄₈O
• 熔点: 168-169°
• 闪点: 219.1±20.7 °C

alpha-菠菜甾醇用途

α-Spinasterol 从 Spinacia oleracea 分离,具有抗菌活性。α-Spinasterol 是一种瞬时受体电位香草酸1 ( TRPV1) 拮抗剂,具有抗炎,抗抑郁,抗氧化和抗伤害作用。α-Spinasterol 抑制 COX-1 和 COX-2 活性,IC50 值分别为 16.17 μM 和 7.76 μM。

alpha-菠菜甾醇名称

• 中文名: a-波菜甾醇
• 英文名: (3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 中文别名: Α-波菜甾醇 | ALPHA-波菜甾醇 | α-菠菜甾醇

alpha-菠菜甾醇生物活性

• 描述: α-Spinasterol 从 Spinacia oleracea 分离,具有抗菌活性。α-Spinasterol 是一种瞬时受体电位香草酸1 ( TRPV1) 拮抗剂,具有抗炎,抗抑郁,抗氧化和抗伤害作用。α-Spinasterol 抑制 COX-1 和 COX-2 活性,IC50 值分别为 16.17 μM 和 7.76 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 感染
  信号通路 >> 免疫及炎症 >> COX
  研究领域 >> 神经疾病
• 靶点实验:

  COX-1:16.17 μM (IC50)

  COX-2:7.76 μM (IC50)

  TRPV1

• 参考文献:

  [1]. Brusco I, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. Br J Pharmacol. 2017 Dec;174(23):4247-4262.

  [2]. Yang X, et al. A novel method for synthesis of α-spinasterol and its antibacterial activities in combination with ceftiofur. Fitoterapia. 2017 Jun;119:12-19.

alpha-菠菜甾醇物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 500.0±44.0 °C at 760 mmHg
• 熔点: 168-169°
• 分子式: C₂₉H₄₈O
• 分子量: 412.691
• 闪点: 219.1±20.7 °C
• 精确质量: 412.370514
• PSA: 20.23000
• LogP: 10.13
• InChIKey: JZVFJDZBLUFKCA-FXIAWGAOSA-N
• SMILES: CCC(C=CC(C)C1CCC2C3=CCC4CC(O)CCC4(C)C3CCC21C)C(C)C
• 外观性状: 粉末
• 蒸汽压: 0.0±2.9 mmHg at 25°C
• 折射率: 1.531
• 储存条件: 2-8℃

alpha-菠菜甾醇毒性和生态

alpha-菠菜甾醇安全信息

• 危害码 (欧洲): Xi

alpha-菠菜甾醇靶点实验

查看更多实验

实验名称：Inhibition of Sprague-Dawley rat lens aldose reductase 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1 External Id：CHEMBL2013617

实验名称：Inhibition of advanced glycation end-products formation after 14 days by spectrofluor... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2013616

实验名称：Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL942189

实验名称：Inhibition of NADPH oxidase in LPS-induced mouse BV2 cells assessed as NOX-dependent ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL942188

实验名称：Anti-austerity activity against nutrient-deprived human PANC1 cells assessed as cell ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL4416800

实验名称：Cytotoxicity against nutrient-rich DMEM cultured human PANC1 cells at PC50 incubated ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL4416805

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alpha-菠菜甾醇英文别名

• a-Spinasterin
• Bessisterol
• UNII:0LG993QX1A
• Spinasterol
• (3b,5a,22E)-Stigmasta-7,22-dien-3-ol
• Alpha-Spinasterol
• spinasta-7,22-dien-3-ol
• Hitodesterol
• Chondrillasterol
• a-Spinasterol
• α-Spinasterin
• (3β,5α,22E)-Stigmasta-7,22-dien-3-ol