B-Raf IN 10

Modify Date: 2024-04-09 09:54:24

B-Raf IN 10 structure	Common Name	B-Raf IN 10
	CAS Number	1425485-87-5	Molecular Weight	494.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₁F₃N₄O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of B-Raf IN 10

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].

Name	B-Raf IN 10

Description	B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	BRAF-V600E:< 50 nM (IC50) Braf:50-100 nM (IC50)
In Vitro	B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1]. B-Raf IN 10 shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1]. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1]. Cell Viability Assay[1] Cell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
References	[1]. Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. Patent US20130053384 A1.

Molecular Formula	C₂₂H₂₁F₃N₄O₄S
Molecular Weight	494.49