2413901-61-6

2413901-61-6 structure

Name: Topoisomerase II inhibitor 9
Chemical Name: Topoisomerase II inhibitor 9
CAS Number: 2413901-61-6
Molecular Formula: C₂₂H₁₇N₇O₃S₂
Molecular Weight: 491.55
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-10 11:10:47
Modify Date: 2024-01-18 09:32:35
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].

Name	Topoisomerase II inhibitor 9

Description	Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II:0.97 μM (IC50)
In Vitro	Topoisomerase II inhibitor 9 (Compound 19b) shows antiproliferative activity with IC50 values of 0.50 ± 0.1, 0.75 ± 0.1 and 2.91 ± 0.1 μM against Hep G‐2, Hep‐2 and Caco‐2 cells, respectively[1].
References	[1]. Eissa IH, et al. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim). 2019 Nov;352(11):e1900123.

Molecular Formula	C₂₂H₁₇N₇O₃S₂
Molecular Weight	491.55