Kv2.1-syntaxin inhibitor 15

Modify Date: 2024-01-15 01:14:48

Kv2.1-syntaxin inhibitor 15 structure	Common Name	Kv2.1-syntaxin inhibitor 15
	CAS Number	1203036-62-7	Molecular Weight	419.499
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₁N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Kv2.1-syntaxin inhibitor 15

Kv2.1-syntaxin inhibitor 15 (Kv2.1-syntaxin-IN-15, Cpd5) is a small molecule Kv2.1-syntaxin-binding inhibitor (IC50=5.5 uM) with neuroprotective properties.Kv2.1-syntaxin inhibitor 15 competitively binds syntaxin against C1aB-containing Kv2.1 peptides with IC50 of 5.5 uM.Kv2.1-syntaxin inhibitor 15 (10 uM) significantly diminished threo-β-benzyloxyaspartate (TBOA, 75 uM)-induced toxicity neuronal cultures, ameliorated significant cellular damage, by preventing the expression of enhanced Kv2.1-mediated K+ currents.Kv2.1-syntaxin inhibitor 15 is a first-in-class inhibitor of Kv2.1 binding to Syntaxin, likely due to inhibition of the C1a region of Kv2.1 binding to syntaxin.Cpd5 (10 μM) does not affect evoked AMPAR EPSCs in layer 2/3 corticocallosal neurons in the mouse auditory cortex.

Name	Kv2.1-syntaxin inhibitor 15

Description	Kv2.1-syntaxin inhibitor 15 (Kv2.1-syntaxin-IN-15, Cpd5) is a small molecule Kv2.1-syntaxin-binding inhibitor (IC50=5.5 uM) with neuroprotective properties.Kv2.1-syntaxin inhibitor 15 competitively binds syntaxin against C1aB-containing Kv2.1 peptides with IC50 of 5.5 uM.Kv2.1-syntaxin inhibitor 15 (10 uM) significantly diminished threo-β-benzyloxyaspartate (TBOA, 75 uM)-induced toxicity neuronal cultures, ameliorated significant cellular damage, by preventing the expression of enhanced Kv2.1-mediated K+ currents.Kv2.1-syntaxin inhibitor 15 is a first-in-class inhibitor of Kv2.1 binding to Syntaxin, likely due to inhibition of the C1a region of Kv2.1 binding to syntaxin.Cpd5 (10 μM) does not affect evoked AMPAR EPSCs in layer 2/3 corticocallosal neurons in the mouse auditory cortex.
References	1. Yeh CY, et al. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15696-15705.

Description

References

1. Yeh CY, et al. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15696-15705.

Molecular Formula	C₂₃H₂₁N₃O₃S
Molecular Weight	419.499

DC Chemicals Limited
China
Product Name: Kv2.1-syntaxin inhibitor 15
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Kv2.1-syntaxin inhibitor 15 suppliers

Kv2.1-syntaxin inhibitor 15 price

Kv2.1-syntaxin inhibitor 15

Use of Kv2.1-syntaxin inhibitor 15

Names

Kv2.1-syntaxin inhibitor 15 Biological Activity

Chemical & Physical Properties