BRD4 Inhibitor-15
Modify Date: 2025-08-21 18:38:56
BRD4 Inhibitor-15 structure
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Common Name | BRD4 Inhibitor-15 | ||
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| CAS Number | 2761366-60-1 | Molecular Weight | 359.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD4 Inhibitor-15BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1]. |
| Name | BRD4 Inhibitor-15 |
|---|
| Description | BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1]. |
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| Related Catalog | |
| Target |
BRD4(1):18 ± 1.1 nM (IC50) Bcl-2 Bax Caspase-3 Procaspase-3 |
| In Vitro | BRD4 Inhibitor-15 (compound 13) shows potent anti-proliferative activity against enzalutamide-resistant 22RV1 cells and LNCap cells, with IC50 values of 8.27 ± 0.28 and 7.33 ± 0.49 μM, respectively[1]. |
| References |
| Molecular Formula | C22H21N3O2 |
|---|---|
| Molecular Weight | 359.42 |