PF 5006739
Modify Date: 2024-01-21 09:41:01
PF 5006739 structure
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Common Name | PF 5006739 | ||
|---|---|---|---|---|
| CAS Number | 1293395-67-1 | Molecular Weight | 419.455 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 680.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H22FN7O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 365.6±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PF 5006739PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. |
| Name | 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)-4-piperidinyl]-1H-imidazol-5-yl}-2-pyrimidinamine |
|---|---|
| Synonym | More Synonyms |
| Description | PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. |
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| Related Catalog | |
| Target |
CK1δ:3.9 nM (IC50) CK1ϵ:17.0 nM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 680.9±65.0 °C at 760 mmHg |
| Molecular Formula | C22H22FN7O |
| Molecular Weight | 419.455 |
| Flash Point | 365.6±34.3 °C |
| Exact Mass | 419.186981 |
| LogP | 2.26 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.718 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Hazard Codes | T+ |
| RIDADR | UN 2811 6.1 / PGIII |
| 4-{4-(4-Fluorophenyl)-1-[1-(1,2-Oxazol-3-Ylmethyl)piperidin-4-Yl]-1h-Imidazol-5-Yl}pyrimidin-2-Amine |
| 2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]- |
| 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)-4-piperidinyl]-1H-imidazol-5-yl}-2-pyrimidinamine |