ML-209
Modify Date: 2024-06-09 19:56:59
ML-209 structure
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Common Name | ML-209 | ||
|---|---|---|---|---|
| CAS Number | 1334526-14-5 | Molecular Weight | 441.52 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 656.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H31NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 350.7±31.5 °C | |
Use of ML-209(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1]. |
| Name | ML-209 |
|---|---|
| Synonym | More Synonyms |
| Description | (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1]. |
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| Related Catalog | |
| Target |
RORγ:1.1 μM (IC50) |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 656.2±55.0 °C at 760 mmHg |
| Molecular Formula | C25H31NO6 |
| Molecular Weight | 441.52 |
| Flash Point | 350.7±31.5 °C |
| Exact Mass | 441.215149 |
| LogP | 4.66 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.568 |
| 3-(1,3-Benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone |
| ML-209 |
| 1-Propanone, 3-(1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-3-(2-hydroxy-4,6-dimethoxyphenyl)- |