Metallo-β-lactamase-IN-5

Modify Date: 2024-01-02 18:17:33

Metallo-β-lactamase-IN-5 structure	Common Name	Metallo-β-lactamase-IN-5
	CAS Number	1417737-65-5	Molecular Weight	348.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Metallo-β-lactamase-IN-5

Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].

Name	Metallo-β-lactamase-IN-5

Description	Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases. Eur J Med Chem. 2022 Jan 15;228:113975.

Molecular Formula	C₁₉H₁₆N₄O₃
Molecular Weight	348.36

Metallo-β-lactamase-IN-5

Use of Metallo-β-lactamase-IN-5

Names

Metallo-β-lactamase-IN-5 Biological Activity

Chemical & Physical Properties