CJ-13610

Modify Date: 2024-02-04 13:32:38

CJ-13610 structure	Common Name	CJ-13610
	CAS Number	179420-17-8	Molecular Weight	393.50200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₃N₃O₂S	Melting Point	198 - 200 °C
	MSDS	Chinese USA	Flash Point	N/A

Use of CJ-13610

CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM[1]. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

Name	4-[3-[4-(2-methylimidazol-1-yl)phenyl]sulfanylphenyl]oxane-4-carboxamide
Synonym	More Synonyms

Description	CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM[1]. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Fischer L, et al. Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610. Br J Pharmacol. 2004;142(5):861-868.

Melting Point	198 - 200 °C
Molecular Formula	C₂₂H₂₃N₃O₂S
Molecular Weight	393.50200
Exact Mass	393.15100
PSA	96.43000
LogP	5.01510
Storage condition	2-8°C

CJ-13610 MSDS(Chinese)

RIDADR	NONH for all modes of transport

Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.

J. Pharmacol. Exp. Ther. 323(3) , 778-86, (2007)

In this study, we examined the relative contribution of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO), two major proinflammatory pathways up-regulated in liver disease, to the progression of hepa...

Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide