Bromoacetamido-C2-PEG2-NH-Boc

Modify Date: 2024-01-10 22:23:35

Bromoacetamido-C2-PEG2-NH-Boc Structure
Bromoacetamido-C2-PEG2-NH-Boc structure
Common Name Bromoacetamido-C2-PEG2-NH-Boc
CAS Number 182244-33-3 Molecular Weight 369.252
Density 1.3±0.1 g/cm3 Boiling Point 506.5±50.0 °C at 760 mmHg
Molecular Formula C13H25BrN2O5 Melting Point N/A
MSDS N/A Flash Point 260.1±30.1 °C

 Use of Bromoacetamido-C2-PEG2-NH-Boc


Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl [2-(2-{2-[(bromoacetyl)amino]ethoxy}ethoxy)ethyl]carbamate
Synonym More Synonyms

 Bromoacetamido-C2-PEG2-NH-Boc Biological Activity

Description Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 506.5±50.0 °C at 760 mmHg
Molecular Formula C13H25BrN2O5
Molecular Weight 369.252
Flash Point 260.1±30.1 °C
Exact Mass 368.094666
LogP 0.81
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.486

 Synonyms

Carbamic acid, N-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl [2-(2-{2-[(bromoacetyl)amino]ethoxy}ethoxy)ethyl]carbamate
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