Thalidomide-5-propoxyethanamine
Modify Date: 2025-08-27 12:59:27
Thalidomide-5-propoxyethanamine structure
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Common Name | Thalidomide-5-propoxyethanamine | ||
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| CAS Number | 2357107-60-7 | Molecular Weight | 359.38 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 615.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H21N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 326.1±31.5 °C | |
Use of Thalidomide-5-propoxyethanamineThalidomide-5-propoxyethanamine is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1]. |
| Name | 5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
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| Synonym | More Synonyms |
| Description | Thalidomide-5-propoxyethanamine is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1]. |
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| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. Mainolfi, Nello, et al. IRAK DEGRADERS AND USES THEREOF. Patent US20190192668A1. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 615.5±55.0 °C at 760 mmHg |
| Molecular Formula | C18H21N3O5 |
| Molecular Weight | 359.38 |
| Flash Point | 326.1±31.5 °C |
| Exact Mass | 359.148132 |
| LogP | 0.45 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.606 |
| 1H-Isoindole-1,3(2H)-dione, 5-[3-(2-aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)- |
| 5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |