DCN1-UBC12-IN-2

Modify Date: 2025-08-27 14:17:58

DCN1-UBC12-IN-2 Structure
DCN1-UBC12-IN-2 structure
Common Name DCN1-UBC12-IN-2
CAS Number 2374827-47-9 Molecular Weight 542.03
Density N/A Boiling Point N/A
Molecular Formula C23H20ClN7O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DCN1-UBC12-IN-2


DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].

 Names

Name DCN1-UBC12-IN-2

 DCN1-UBC12-IN-2 Biological Activity

Description DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].
Related Catalog
In Vitro DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 27.34 μM for 24 h.
References

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190.

 Chemical & Physical Properties

Molecular Formula C23H20ClN7O3S2
Molecular Weight 542.03
InChIKey ZKZPHQPTGZBOHB-UHFFFAOYSA-N
SMILES COc1cc(-c2nc(SCc3ccc(Cl)cc3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC
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