Acetaminophen Acetate (Acetaminophen Impurity)

Modify Date: 2024-01-05 21:27:50

Acetaminophen Acetate (Acetaminophen Impurity) Structure
Acetaminophen Acetate (Acetaminophen Impurity) structure
Common Name Acetaminophen Acetate (Acetaminophen Impurity)
CAS Number 2623-33-8 Molecular Weight 193.199
Density 1.2±0.1 g/cm3 Boiling Point 376.4±25.0 °C at 760 mmHg
Molecular Formula C10H11NO3 Melting Point 155°C
MSDS Chinese USA Flash Point 181.4±23.2 °C

 Use of Acetaminophen Acetate (Acetaminophen Impurity)


4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic drug, is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2].

 Names

Name (4-acetamidophenyl) acetate
Synonym More Synonyms

  Biological Activity

Description 4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic drug, is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2].
Related Catalog
References

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

[2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 376.4±25.0 °C at 760 mmHg
Melting Point 155°C
Molecular Formula C10H11NO3
Molecular Weight 193.199
Flash Point 181.4±23.2 °C
Exact Mass 193.073898
PSA 55.40000
LogP 0.60
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.561
Storage condition Refrigerator

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles2

More Articles
Analysis of tablets containing aspirin, acetaminophen, and ascorbic acid by high-performance liquid chromatography.

J. Pharm. Sci. 73(12) , 1830-3, (1984)

The high-performance liquid chromatographic method described enables the quantitation of the components and the main impurities of tablets containing aspirin, acetaminophen, and ascorbic acid. A C8 re...

[N,O-diacetyl-p-aminophenol formation by combined use of aspirin with phenacetin and acetaminophen in vivo (author's transl)].

Yakugaku Zasshi 100(10) , 1043-7, (1980)

 Synonyms

4-Acetamidophenyl acetate
Acetaminophen Acetate (Acetaminophen Impurity)
Acetaminophen acetate
EINECS 220-077-6
4-AcNHC6H4OAc
4'-Acetoxyacetanilide
Diacetamat
P-ACETOXYACETANILIDE
Acetaminophen Related Compound A
MFCD00059205
N,O-Diacetyl-4-aminophenol
4-(Acetylamino)phenyl acetate,p-Acetoxyacetanilide
4-Acetoxyacetanilide
Acetamide, N-[4-(acetyloxy)phenyl]-
diacetamate