Bromo-PEG3-bromide
Bromo-PEG3-bromide structure
|
Common Name | Bromo-PEG3-bromide | ||
|---|---|---|---|---|
| CAS Number | 31255-26-2 | Molecular Weight | 320.01900 | |
| Density | 1.57 g/cm3at 25°C (lit.) | Boiling Point | 146 °C at 0.06 Torr (lit.) | |
| Molecular Formula | C8H16Br2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bromo-PEG3-bromideBromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 1-(2-bromoethoxy)-2-[2-(2-bromoethoxy)ethoxy]ethane |
|---|---|
| Synonym | More Synonyms |
| Description | Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.57 g/cm3at 25°C (lit.) |
|---|---|
| Boiling Point | 146 °C at 0.06 Torr (lit.) |
| Molecular Formula | C8H16Br2O3 |
| Molecular Weight | 320.01900 |
| Exact Mass | 317.94700 |
| PSA | 27.69000 |
| LogP | 1.82600 |
| Hazard Codes | Xi |
|---|
|
~88%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290 |
|
~68%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Hurley, Christopher A.; Wong, John B.; Ho, Jimmy; Writer, Michele; Irvine, Scott A.; Lawrence, M. Jayne; Hart, Stephen L.; Tabor, Alethea B.; Hailes, Helen C. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 14 p. 2554 - 2559 |
|
~66%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Breyholz, Hans-Joerg; Wagner, Stefan; Faust, Andreas; Riemann, Burkhard; Hoeltke, Carsten; Hermann, Sven; Schober, Otmar; Schaefers, Michael; Kopka, Klaus ChemMedChem, 2010 , vol. 5, # 5 p. 777 - 789 |
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~%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; C.-Gaudreault, Rene; Berube, Gervais Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 557 - 560 Title/Abstract Full Text View citing articles Show Details Berube, Gervais; Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; Gaudreault, Rene-C.; Parent, Sophie; Asselin, Eric Steroids, 2006 , vol. 71, # 10 p. 911 - 921 |
|
~%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Nesmejanow et al. Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951 , p. 708,709 Chem.Abstr., 1952 , p. 7514 |
|
~%
Bromo-PEG3-bromide CAS#:31255-26-2 |
| Literature: Delaney, Paul A.; Johnstone, Robert A. W.; Entwistle, Ian D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1855 - 1860 |
| Precursor 7 | |
|---|---|
| DownStream 9 | |
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