Pentaethylene glycol di(p-toluenesulfonate)

Modify Date: 2024-01-03 01:09:14

Pentaethylene glycol di(p-toluenesulfonate) Structure
Pentaethylene glycol di(p-toluenesulfonate) structure
Common Name Pentaethylene glycol di(p-toluenesulfonate)
CAS Number 41024-91-3 Molecular Weight 546.65100
Density 1.26 Boiling Point 661.4ºC at 760mmHg
Molecular Formula C24H34O10S2 Melting Point N/A
MSDS Chinese USA Flash Point 353.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Pentaethylene glycol di(p-toluenesulfonate)


Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name penta(ethylene glycol) di-p-toluenesulfonate
Synonym More Synonyms

  Biological Activity

Description Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.26
Boiling Point 661.4ºC at 760mmHg
Molecular Formula C24H34O10S2
Molecular Weight 546.65100
Flash Point 353.8ºC
Exact Mass 546.15900
PSA 140.42000
LogP 4.64220
Index of Refraction n20/D 1.524(lit.)
Water Solubility Not miscible or difficult to mix in water.

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2909499000

 Synthetic Route

~10%

Pentaethylene glycol di(p-toluenesulfonate) Structure

Pentaethylene g...

CAS#:41024-91-3

Literature: Bouzide, Abderrahim; Sauve, Gilles Organic Letters, 2002 , vol. 4, # 14 p. 2329 - 2332

~99%

Pentaethylene glycol di(p-toluenesulfonate) Structure

Pentaethylene g...

CAS#:41024-91-3

Literature: Bonger, Kimberly M.; van den Berg, Richard J.B.H.N.; Heitman, Laura H.; IJzerman, Ad P.; Oosterom, Julia; Timmers, Cornelis M.; Overkleeft, Herman S.; van der Marel, Gijsbert A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4841 - 4856

~%

Pentaethylene glycol di(p-toluenesulfonate) Structure

Pentaethylene g...

CAS#:41024-91-3

Literature: Fenton, David E.; Parkin, Donald; Newton, Roger F. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 449 - 454

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles4

More Articles

Pure Appl. Chem. 65 , 585, (1993)

Tetrahedron 49 , 6019, (1993)

Chem Express 8 , 471, (1993)

 Synonyms

Pentaethylene glycol di-p-toluenesulfonate
2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
MFCD00012204
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