NH-3
Modify Date: 2024-01-02 19:27:25
NH-3 structure
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Common Name | NH-3 | ||
|---|---|---|---|---|
| CAS Number | 447415-26-1 | Molecular Weight | 473.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NH-3NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. |
| Name | NH-3 |
|---|
| Description | NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: 55 nM (THR)[1] |
| In Vivo | NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose[2]. |
| References |
| Molecular Formula | C28H27NO6 |
|---|---|
| Molecular Weight | 473.52 |