HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu

Modify Date: 2024-01-04 06:28:04

HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure
HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu structure
Common Name HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu
CAS Number 564476-33-1 Molecular Weight 282.35400
Density N/A Boiling Point N/A
Molecular Formula C15H30O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu


Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Sulfanyl-3,6,9,12-tetraoxapentadecan-15-oic acid
Synonym More Synonyms

 HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Biological Activity

Description Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C15H30O6S
Molecular Weight 282.35400
Exact Mass 282.11400
PSA 113.02000
LogP 0.45730

 Synthetic Route

~85%

HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: ImmunoGen, Inc. Patent: US2004/1838 A1, 2004 ;

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HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805

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HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805

~%

HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805

~%

HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805

~%

HS-PEG4-CH2CH2COO<SUP>t</SUP>Bu Structure

HS-PEG4-CH2CH2C...

CAS#:564476-33-1

Literature: Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805

 Synonyms

15-mercapto-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester
15-Keto-1-dehydro-testololacton
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