DL-Homocysteine

Modify Date: 2024-01-04 14:42:01

DL-Homocysteine Structure
DL-Homocysteine structure
Common Name DL-Homocysteine
CAS Number 6027-13-0 Molecular Weight 135.185
Density 1.3±0.1 g/cm3 Boiling Point 299.7±35.0 °C at 760 mmHg
Molecular Formula C4H9NO2S Melting Point 231 °C
MSDS Chinese USA Flash Point 135.0±25.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of DL-Homocysteine


L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].

 Names

Name L-homocysteine
Synonym More Synonyms

 DL-Homocysteine Biological Activity

Description L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Finkelstein JD, et al. Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9.

[2]. Leng YP, et al. l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Br J Pharmacol. 2018 Apr;175(8):1157-1172.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 299.7±35.0 °C at 760 mmHg
Melting Point 231 °C
Molecular Formula C4H9NO2S
Molecular Weight 135.185
Flash Point 135.0±25.9 °C
Exact Mass 135.035400
PSA 102.12000
LogP 0.22
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.538
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport

 Synthetic Route

 Articles86

More Articles
Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.

J. Nutr. 144(5) , 714-21, (2014)

Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may als...

Abstracts of the 9th International Conference On Homocysteine and One-Carbon Metabolism - HCY2013. Dublin, Ireland. September 8-12, 2013.

J. Inherit. Metab. Dis. 36 Suppl 1 , S1-54, (2013)

Derivation and validation of homocysteine score in u.s. Men and women.

J. Nutr. 145(1) , 96-104, (2015)

One-carbon metabolism, which is crucial in DNA synthesis and genomic stability, is an interrelated network of biochemical reactions involved in several dietary and lifestyle factors. The development o...

 Synonyms

(2S)-2-amino-4-sulfanylbutanoic acid
Homocysteine, L-
L-2-Amino-4-Mercapto-butyric acid
(S)-2-amino-4-mercapto-Butanoic acid
DL-2-amino-4-mercapto-Butyric acid
HOMO-CYS
H-Hcys-OH
Butyric acid, 2-amino-4-mercapto-
DL-2-Amino-4-mercaptobutyric acid
Butyric acid, 2-amino-4-mercapto-, DL-
(S)-2-Amino-4-mercaptobutanoic acid
2-Amino-4-mercaptobutyric acid
D,L-Homocysteine
Butanoic acid, 2-amino-4-mercapto-, (S)-
(S)-homocysteine
MFCD00151320
Butanoic acid, 2-amino-4-mercapto-
2-amino-4-mercapto-DL-Butyric acid
2-amino-4-sulfanylbutanoic acid
EINECS 227-891-0
D,L-homocystine
Homocysteine (VAN)
2-Amino-4-Mercapto-Butyric Acid
(S)-2-Amino-4-mercaptobutyric acid
(±)-Homocysteine
2-amino-4-mercapto-Butanoic acid
UNII:S7IJP4A89K
Homocysteine
Butyric acid, 2-amino-4-mercapto-, DL- (9CI)
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