Phenoxybenzamine HCl
Modify Date: 2026-07-03 12:12:46
Phenoxybenzamine HCl structure
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Common Name | Phenoxybenzamine HCl | ||
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| CAS Number | 63-92-3 | Molecular Weight | 340.287 | |
| Density | N/A | Boiling Point | 381.5ºC at 760 mmHg | |
| Molecular Formula | C18H23Cl2NO | Melting Point | 137.5°C | |
| MSDS | Chinese USA | Flash Point | 184.5ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
Use of Phenoxybenzamine HClPhenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Phenoxybenzamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma. |
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| Related Catalog | |
| In Vitro | The IC50 (100 nM) derived from the blockade of [3H]yohimbine binding by Phenoxybenzamine hydrochloride is significantly less than the IC50 (550 nM) for the corresponding reversal by Phenoxybenzamine hydrochloride of the effects of norepinephrine on cyclic AMP accumulation[1]. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM). In addition, combined treatment with Phenoxybenzamine hydrochloridetolamine and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride combined treatment. Combined treatment with high concentrations of dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with combined treatment with low concentrations of dexmedetomidine (300 nM) and Phenoxybenzamine hydrochloride[2]. Phenoxybenzamine hydrochloride (0.1-100 μM) inhibits glioma proliferation, migration, and invasion and suppresses the tumorigenesis capacity. Phenoxybenzamine hydrochloride also inhibits self-renewal of glioma stem-like cells. Phenoxybenzamine hydrochloride activates LINGO-1 and inhibits the TrkB-Akt pathway[3]. Phenoxybenzamine hydrochloride (0.1 μM-1 mM) preserves primary neurons within the CA1, CA3 and dentate gyrus and produces a robust neuroprotective effect, and prevents neuronal death from OGD in all regions of the hippocampus when delivered at 2, 4, and 8 h post-OGD at 100 μM[4]. |
| In Vivo | Phenoxybenzamine hydrochloride (20 nM, s.c.) effectively suppresses the tumorigenesis of glioma cells in mice and the cell density in Phenoxybenzamine hydrochloride-U87MG xenografts decreases significantly[3]. Phenoxybenzamine hydrochloride (1 mg/kg, i.v.) treated rats shows significant improvements in NSS and foot fault scoring[4]. |
| Cell Assay | After cytometry, 1×3 cells are implanted in a 96-well plate in 100 μL DMEM supplemented with 10 % FBS. Ten microliter (10 % of the total volume) WST-1 (Water Soluble Tetrazolium) is added to cells and incubated at 37°C for 30 min before colorimetric assay with 450 nm excitation and 630 nm emission at 24 h intervals up to 96 h. The mean fluorescence value is counted, and the cell number is determined using the standard curve. |
| Animal Admin | U87MG cells are injected into both flanks of the nude mice subcutaneously at a dose of 2.0×3/200 μL per side. Eight days after injection, neoplasm growth is observed macroscopically on both sides of the mice. Then, 20 nM phenoxybenzamine hydrochloride is injected into the right side subcutaneously at a 2-day interval, and the dissolvent DMSO is used as control. The tumor volume (V) is determined by measuring the length (a) and the width (b) and calculated using the equation: V=(ab)2/2. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 381.5ºC at 760 mmHg |
|---|---|
| Melting Point | 137.5°C |
| Molecular Formula | C18H23Cl2NO |
| Molecular Weight | 340.287 |
| Flash Point | 184.5ºC |
| Exact Mass | 339.115662 |
| PSA | 12.47000 |
| LogP | 4.99690 |
| InChIKey | VBCPVIWPDJVHAN-UHFFFAOYSA-N |
| SMILES | CC(COc1ccccc1)N(CCCl)Cc1ccccc1.Cl |
| Storage condition | 2-8°C |
| Water Solubility | H2O: slightly soluble | <0.01 g/100 mL at 18.5 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H351 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R40 |
| Safety Phrases | S22-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DP3750000 |
| HS Code | 2922299090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922299090 |
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| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Neurotransmitter-mediated anxiogenic action of PACAP-38 in rats.
Behav. Brain Res. 281 , 333-8, (2015) The action of PACAP-38 was studied by measuring the anxiogenic-anxiolytic behavior of rats in an elevated plus maze. PACAP-38 was administered into the lateral brain ventricle and the behavior of the ... |
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Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.
Sci. Rep. 5 , 10405, (2015) The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy homeostasis, and cell p... |
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Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery.
J. Antimicrob. Chemother. 65(11) , 2347-58, (2010) To identify inhibitors of the essential chromosome partitioning protein ParA that are active against Mycobacterium tuberculosis.Antisense expression of the parA orthologue MSMEG_6939 was induced on th... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Cell Viability Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPV101
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Name: Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPC101
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5066378
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride |
| Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (1:1) |
| N-benzyl-N-(2-chloroéthyl)-1-phénoxypropan-2-amine chlorhydrate |
| MFCD00599580 |
| N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine,hydrochloride |
| Bensylyte Hydrochloride |
| N-Benzyl-N-(2-chlorethyl)-1-phenoxypropan-2-aminhydrochlorid |
| Dibenyline |
| Benzenemethanamine, N- (2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride |
| Benzylamine, N- (2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride |
| Phenoxybenzamine HCl |
| N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine, hydrochloride |
| (±)-Phenoxybenzamine Hydrochloride |
| N-Phenoxyisopropyl-N-benzyl-b-chloroethylamine Hydrochloride |
| N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine hydrochloride (1:1) |
| Bensylyt Hydrochloride |
| Phenoxybenzamine Hydrochloride |
| EINECS 200-569-7 |
| Dibenzyran |
| N-Benzyl-N-(2-chloroethyl)-1-phenoxy-2-propanamine hydrochloride (1:1) |
| Phenoxybenzamine (hydrochloride) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the storage conditions for Phenoxybenzamine hydrochloride? |
| A: Storage conditions for Phenoxybenzamine hydrochloride: 2-8°C. |
| Q: What is the SMILES notation of Phenoxybenzamine hydrochloride? |
| A: SMILES notation of Phenoxybenzamine hydrochloride is CC(COc1ccccc1)N(CCCl)Cc1ccccc1.Cl. |
| Q: What is the boiling point of Phenoxybenzamine hydrochloride? |
| A: Boiling point of Phenoxybenzamine hydrochloride is 381.5ºC at 760 mmHg. |
| Q: What is the molecular formula of Phenoxybenzamine hydrochloride? |
| A: Molecular formula of Phenoxybenzamine hydrochloride is C18H23Cl2NO. |
| Q: What is the molecular weight of Phenoxybenzamine hydrochloride? |
| A: Molecular weight of Phenoxybenzamine hydrochloride is 340.287. |
| Q: What are the uses of Phenoxybenzamine hydrochloride? |
| A: Main uses of Phenoxybenzamine hydrochloride: Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma. |
| Q: How is the water solubility of Phenoxybenzamine hydrochloride? |
| A: Water solubility of Phenoxybenzamine hydrochloride: H2O: slightly soluble | <0.01 g/100 mL at 18.5 ºC. |
| Q: What is the polar surface area (PSA) of Phenoxybenzamine hydrochloride? |
| A: Polar surface area (PSA) of Phenoxybenzamine hydrochloride is 12.47000. |
| Q: What is the LogP of Phenoxybenzamine hydrochloride? |
| A: LogP of Phenoxybenzamine hydrochloride is 4.99690. |
| Q: What is the safety information for Phenoxybenzamine hydrochloride? |
| A: Safety information for Phenoxybenzamine hydrochloride: S22-S36/37/39-S45. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |