73-03-0

73-03-0 structure

Name: Cordycepin
Chemical Name: Cordycepin
CAS Number: 73-03-0
Molecular Formula: C₁₀H₁₃N₅O₃
Molecular Weight: 251.242
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-03-02 08:00:00
Modify Date: 2026-06-30 07:51:12
Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.

Name	Cordycepin
Synonyms	CORDYECIN (3''-DEOXYADENOSINE) 3'-Deoxyadenosine(cordycin) EINECS 200-791-4 Cordycin (3-deoxyadenosine), Nucleoside antagonist Cordycine 3'-dA 3'-Deoxyadenosine 2-ACETYL-5-CHLORO-112-METHYLTHIANAPHTHENE TIANFU-CHEM - Cordycin Cipgamin β-D-erythro-Pentofuranoside,adenine-9 3-deoxy CORDYCIN_-0 CORDYCIN 9-[3-Deoxy-3-(hydroxymethyl)-b-D-erythrofuranosyl]adenine Cordycin,HPLC Cordycepine MFCD00037998 Cordycs Mycelia powder Adenosine, 3-deoxy 9-Cordycosidoadenosine Cordycs sinensis(Berk. )Sacc Cordycin powder //BP cordycepin crystalline 3’-Deoxyadenosine, Cordycine 4-[3-(4-Hydroxy-2-methylphenyl)-1,1-dioxobenzo[c]oxathiol-3-yl]-3-methylphenol Adenosine 3'-deoxyriboside CORDYCIN [3''-DEOXYADENOSINE] 3'-Deoxy-D-adenosine Cordycin //BP Cresolsulphonhthalein 3-Deoxyribosyl adenine Cordycin-RM Cordycin, 10 mM in DMSO Cordycin Hydrate Cordycs Sinensis fruiting body Cordyceps fungus powder 3’-Deoxyadenosine(cordycin) Cordycin from Cordycs militis (-)-cordycepin 9-cordycosidoadenine Adenine cordycoside chonaoduitang 9-(3-Deoxy-b-D-ribofuranosyl)adenine Adenine cordyceposide 9-(.beta.-d-3'-deoxyribofuranosyl)adenine 3'-Deoxyadenosine, 9CI,8CI Adenosine,3-deoxy Cordycin Hydrate> adenosine, 3'-deoxy- (8ci9ci) 9-(3-Deoxy-D-erythro-pentofuranosyl)-9H-purin-6-amine (2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3-ol 3'-DEOXYADENOSINE 9-(3-Deoxy-D-ribofuranosyl)adenine Cordycin > 3’-deoxy-adenosin 9-(3-Deoxy-b-D-erythro-pentofuranosyl)-9H-purin-6-amine cordycin crystalline Cordycin in Water 9-(3-deoxypentofuranosyl)-9H-purin-6-amine

Description	Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MMP-1 MMP-3
In Vitro	Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1].
Cell Assay	RASFs (2×104 cells/well) are treated with various concentrations of Cordycepin (50 μM or 100 μM). After incubation for 1 h, 12 h and 24 h, cells are washed twice with PBS, MTT (0.5 mg/mL PBS) is added to each well and incubated at 37°C for 30 min. Formazan crystals formed are dissolved by adding DMSO (100 μL/well) and the absorbance is read at 570 nm using a microplate reader[1].
References	[1]. Noh EM, et al. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8.

Density	1.9±0.1 g/cm3
Boiling Point	627.2±65.0 °C at 760 mmHg
Melting Point	225-229ºC
Molecular Formula	C₁₀H₁₃N₅O₃
Molecular Weight	251.242
Flash Point	333.1±34.3 °C
Exact Mass	251.101837
PSA	119.31000
LogP	-0.41
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.863
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7358610

CHEMICAL NAME :: Adenosine, 3'-deoxy-

CAS REGISTRY NUMBER :: 73-03-0

BEILSTEIN REFERENCE NO. :: 0035194

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H13-N5-O3

MOLECULAR WEIGHT :: 251.28

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- BT5OTJ CQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 20 mg/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,119,1982

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S45
RIDADR	UN 2811
WGK Germany	3
RTECS	AU7358610
HS Code	29349990

Precursor 6
2627-64-7 116285-72-4 71196-28-6 51763-58-7
4395-38-4 58-61-7
DownStream 7
4097-22-7 189887-77-2 207347-42-0 17434-81-0
110143-10-7 76902-49-3 84138-86-3

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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