PF-00356231 hydrochloride
Modify Date: 2024-01-17 11:24:30
PF-00356231 hydrochloride structure
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Common Name | PF-00356231 hydrochloride | ||
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| CAS Number | 820223-77-6 | Molecular Weight | 464.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H21ClN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-00356231 hydrochloridePF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. |
| Name | PF-00356231 hydrochloride |
|---|
| Description | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. |
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| Related Catalog | |
| Target |
MMP-12:1.4 μM (IC50) MMP13:0.65 nM (IC50) MMP-3:0.39 μM (IC50) MMP-8:1.7 μM (IC50) MMP-9:0.98 μM (IC50) |
| In Vitro | PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1]. |
| References |
| Molecular Formula | C25H21ClN2O3S |
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| Molecular Weight | 464.96 |