m-PEG8-O-alkyne

Modify Date: 2024-01-14 18:28:36

m-PEG8-O-alkyne structure	Common Name	m-PEG8-O-alkyne
	CAS Number	880081-81-2	Molecular Weight	422.51000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₃₈O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of m-PEG8-O-alkyne

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne
Synonym	More Synonyms

Description	m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₂₀H₃₈O₉
Molecular Weight	422.51000
Exact Mass	422.25200
PSA	83.07000
LogP	0.39880

mPEG8-CH2C≡CH