m-PEG8-thiol

Modify Date: 2024-01-04 18:15:20

m-PEG8-thiol Structure
m-PEG8-thiol structure
Common Name m-PEG8-thiol
CAS Number 651042-83-0 Molecular Weight 400.52800
Density 1.07 Boiling Point N/A
Molecular Formula C17H36O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of m-PEG8-thiol


m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol
Synonym More Synonyms

 m-PEG8-thiol Biological Activity

Description m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.07
Molecular Formula C17H36O8S
Molecular Weight 400.52800
Exact Mass 400.21300
PSA 112.64000
LogP 0.67880
Storage condition 2-8°C

 Synonyms

2,5,8,11,14,17,20,23-octaoxapentacosane-25-thiol
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