N3-C3-NHS ester

Modify Date: 2025-08-25 15:38:50

N3-C3-NHS ester Structure
N3-C3-NHS ester structure
Common Name N3-C3-NHS ester
CAS Number 943858-70-6 Molecular Weight 226.18900
Density N/A Boiling Point N/A
Molecular Formula C8H10N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N3-C3-NHS ester


N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name Butanoic acid, 4-azido-, 2,5-dioxo-1-pyrrolidinyl ester
Synonym More Synonyms

 N3-C3-NHS ester Biological Activity

Description N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

Noncleavable

References

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

 Chemical & Physical Properties

Molecular Formula C8H10N4O4
Molecular Weight 226.18900
Exact Mass 226.07000
PSA 113.43000
LogP 0.07476
InChIKey YYULROINNKAMIB-UHFFFAOYSA-N
SMILES [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O

 Safety Information

HS Code 2929909090

 Customs

HS Code 2929909090
Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

4-azidobutyrate-n-hydroxysuccinimide ester
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