N3-C3-NHS ester

Modify Date: 2024-01-02 00:04:55

N3-C3-NHS ester Structure
N3-C3-NHS ester structure
Common Name N3-C3-NHS ester
CAS Number 943858-70-6 Molecular Weight 226.18900
Density N/A Boiling Point N/A
Molecular Formula C8H10N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N3-C3-NHS ester


N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name Butanoic acid, 4-azido-, 2,5-dioxo-1-pyrrolidinyl ester
Synonym More Synonyms

 N3-C3-NHS ester Biological Activity

Description N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

Noncleavable

References

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

 Chemical & Physical Properties

Molecular Formula C8H10N4O4
Molecular Weight 226.18900
Exact Mass 226.07000
PSA 113.43000
LogP 0.07476

 Safety Information

HS Code 2929909090

 Customs

HS Code 2929909090
Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

4-azidobutyrate-n-hydroxysuccinimide ester
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