Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA structure
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Common Name | Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA | ||
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CAS Number | 199807-33-5 | Molecular Weight | 688.653 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C28H39F3N8O9 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Cyclo(Arg-Gly-Asp-D-Phe-Val) TFACyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity. |
Name | Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA |
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Synonym | More Synonyms |
Description | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity. |
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Related Catalog | |
Target |
αvβ3[1] |
In Vitro | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1]. |
Cell Assay | The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1]. |
References |
Molecular Formula | C28H39F3N8O9 |
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Molecular Weight | 688.653 |
Exact Mass | 688.279236 |
Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) trifluoroacetate (1:1) |
Acetic acid, 2,2,2-trifluoro-, compd. with cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) (1:1) |