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茴香脑

茴香脑用途

Anethole是一类芳香族化合物,用作调味物,是Phenylpropene的衍生物,广泛存在于自然界。

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茴香脑名称

[ CAS 号 ]:
104-46-1

[ 中文名 ]:
茴香脑

[ 英文名 ]:
cis-Anethol

[中文别名 ]:

[英文别名 ]:

Benzene, 1-methoxy-4-[(1E)-1-propen-1-yl]-
Benzene, 1-methoxy-4- (1-propenyl)-, (E)-
trans-4-(1-Propenyl)anisole
trans-p-Propenylanisole
(E)-1-methoxy-4-(prop-1-en-1-yl)benzene
1-methoxy-4-[(1E)-prop-1-en-1-yl]benzene
trans-4-Propenylanisole
Anise camphor
1-Methoxy-4-[(1E)-1-propen-1-yl]benzene
Nauli gum

茴香脑生物活性

[ 描述 ]:

Anethole是一类芳香族化合物,用作调味物,是Phenylpropene的衍生物,广泛存在于自然界。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

天然产物 >> 苯丙酸类

[相关活性小分子]

茴香脑物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
237.5±9.0 °C at 760 mmHg

[ 熔点 ]:
20-21 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂O

[ 分子量 ]:
148.202

[ 闪点 ]:
90.6±0.0 °C

[ 精确质量 ]:
148.088821

[ PSA ]:
9.23000

[ LogP ]:
3.17

[ 外观性状 ]:
无色,透明液体

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.545

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

茴香脑MSDS

详细MSDS(安全技术说明书)

茴香脑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8925000

CHEMICAL NAME :: Anisole, p-propenyl-

CAS REGISTRY NUMBER :: 104-46-1

BEILSTEIN REFERENCE NO. :: 0774229

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H12-O

MOLECULAR WEIGHT :: 148.22

WISWESSER LINE NOTATION :: 2U1R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2090 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 17,497,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3050 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 593 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,863,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2160 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,3069,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1381 No. of Facilities: 38 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 511 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1381 No. of Facilities: 4061 (estimated) No. of Industries: 49 No. of Occupations: 46 No. of Employees: 58125 (estimated) No. of Female Employees: 15589 (estimated)

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茴香脑安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S36/37

[ WGK德国 ]:
2

[ RTECS号 ]:
BZ9275000

[ 海关编码 ]:
2909309090

茴香脑合成路线

详细合成路线

茴香脑上下游产品

茴香脑上游产品

茴香脑下游产品

茴香脑制备

1. 茴香脑在工业制法有多种，现介绍以下几种。（1）将茴香油或大茴香油冷却，析出结晶，经蒸馏并用酒精再结晶可得。也可以对茴香油精馏，收集230-234℃的馏了出物。或减压精馏，收集142℃（5.60kPa）或110℃（2.7kPa）馏分，即得茴香脑。（2）由对甲氧基苯基丁烯酸经220-240℃加热而得。（3）将对丙烯基苯甲醚与苛性碱一起加热，异构化为茴香脑。（4）由对丙烯基苯酚甲基化而得。（5）茴香醛与G2H5MgX作用，将生成物加热水脱水得到茴香脑。（6）茴香醛与丙酸酐及丙酸钠一起加热得到茴香脑。（7）在茴香醚和丙醛混合物中，于0℃加入浓盐酸和磷酸，使氯化氢气体达饱和，将产物与吡啶一起加热脱去氯化氢，即得到茴香脑。也可用氢溴酸代替浓盐酸，产物用金属钠处理，脱溴化氢即得到茴香脑。（8）将对溴茴香醚制备成Grignard试剂，并与烯丙基溴反应，生成对甲氧基苯丙烯，然后与氢氧化钾一起加热，异构化得到茴香脑。

2. 烟草：BU，14。

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茴香脑海关

[ 海关编码 ]: 2909309090

[ 中文概述 ]:
2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

茴香脑

茴香脑用途

茴香脑名称

茴香脑生物活性

茴香脑物理化学性质

茴香脑MSDS

详细MSDS(安全技术说明书)

茴香脑毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

茴香脑安全信息

茴香脑合成路线

详细合成路线

茴香脑上下游产品

茴香脑上游产品

茴香脑下游产品

茴香脑制备

茴香脑海关

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