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舍吲哚

舍吲哚用途

Sertindole是5-HT2A,5-HT2C,D2和αl受体拮抗剂。

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舍吲哚名称

[ CAS 号 ]:
106516-24-9

[ 中文名 ]:
舍吲哚

[ 英文名 ]:
SERTINDOLE

[中文别名 ]:

[英文别名 ]:

MFCD00867749
Sertindole

舍吲哚生物活性

[ 描述 ]:

Sertindole是5-HT2A,5-HT2C,D2和αl受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Juruena, M.F., E.P. de Sena, and I.R. de Oliveira, Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis, 2011. 3: p. 75-85.

[2]. Kane, J.M. and C.A. Tamminga, Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic. Expert Opin Investig Drugs, 1997. 6(11): p. 1729-41.

[3]. Murdoch, D. and G.M. Keating, Sertindole : a review of its use in schizophrenia. CNS Drugs, 2006. 20(3): p. 233-55.

[相关活性小分子]

舍吲哚物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
592.1±50.0 °C at 760 mmHg

[ 熔点 ]:
95-100ºC

[ 分子式 ]:
C₂₄H₂₆ClFN₄O

[ 分子量 ]:
440.941

[ 闪点 ]:
311.9±30.1 °C

[ 精确质量 ]:
440.177917

[ PSA ]:
40.51000

[ LogP ]:
5.26

[ 外观性状 ]:
off-white

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: >10mg/mL

舍吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H413

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NJ0621100

舍吲哚合成路线

详细合成路线

舍吲哚上下游产品

舍吲哚上游产品

舍吲哚下游产品

舍吲哚制备

化合物(I)和化合物(Ⅱ)进行格氏反应后，生成物(Ⅲ)水解，即得产物。

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舍吲哚文献

An investigation of the stability of emerging new psychoactive substances.

Drug Test. Anal. 6(7-8) , 696-704, (2014)

The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detec...

Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices.

Eur. J. Neurosci. 36(12) , 3628-35, (2012)

Agents such as sertindole and astemizole affect heart action by inducing long-QT syndrome, suggesting that apart from their neuronal actions through histamine receptors, 5-HT2 serotonin receptors and ...

Risperidone versus other atypical antipsychotics for schizophrenia.

Cochrane Database Syst. Rev. (1) , CD006626, (2011)

In many countries of the industrialised world second-generation ("atypical") antipsychotics (SGAs) have become the first line drug treatment for people with schizophrenia. The question as to whether a...

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舍吲哚