残杀威
残杀威用途
残杀威名称
[ CAS 号 ]:
114-26-1
[ 中文名 ]:
残杀威
[ 英文名 ]:
Propoxur
[中文别名 ]:
[英文别名 ]:
- 2-(1-methylethoxy)phenyl N-methylcarbamate
- 2-(propan-2-yloxy)phenyl methylcarbamate
- Aprocarb
- Baygon
- Propoxur
- PHC
- arprocarb
- 2-[(1-methylethyl)oxy]phenyl methylcarbamate
- Phenol, 2-(1-methylethoxy)-, methylcarbamate
- Propoxur solution
残杀威生物活性
残杀威物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
327.2±44.0 °C at 760 mmHg
[ 熔点 ]:
91°C
[ 分子式 ]:
C11H15NO3
[ 分子量 ]:
209.242
[ 闪点 ]:
151.7±28.4 °C
[ 精确质量 ]:
209.105194
[ PSA ]:
47.56000
[ LogP ]:
2.56
[ 外观性状 ]:
白色至黄褐色的结晶粉末
[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C
[ 折射率 ]:
1.499
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 水溶解性 ]:
略溶于水. 0.2 G/100 ML
残杀威MSDS
残杀威毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FC3150000
- CHEMICAL NAME :
- Carbamic acid, methyl-, o-isopropoxyphenyl ester
- CAS REGISTRY NUMBER :
- 114-26-1
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 58
- MOLECULAR FORMULA :
- C11-H15-N-O3
- MOLECULAR WEIGHT :
- 209.27
- WISWESSER LINE NOTATION :
- 1Y1&OR BOVM1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Cardiac - pulse rate Blood - change in clotting factors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1440 mg/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23500 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1360 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 7500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 46500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - duck
- DOSE/DURATION :
- 9580 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 3800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 864 mg/kg/13W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Biochemical - Metabolism (Intermediary) - other
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37500 ug/kg/50D-C
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Endocrine - changes in thymus weight Biochemical - Metabolism (Intermediary) - other proteins
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 180 mg/kg/30D-I
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1600 mg/kg
- SEX/DURATION :
- female 6-22 day(s) after conception lactating female 15 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 650 mg/kg
- SEX/DURATION :
- female 7-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 7-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 7-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TEST SYSTEM :
- Rodent - hamster
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 58,152,1986 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3 JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3 JAN 1993 OEL-GERMANY:TWA 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 2 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PROPOXUR-air:10H TWA 0.5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1931 No. of Facilities: 2519 (estimated) No. of Industries: 18 No. of Occupations: 14 No. of Employees: 18098 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1931 No. of Facilities: 2701 (estimated) No. of Industries: 15 No. of Occupations: 16 No. of Employees: 27304 (estimated) No. of Female Employees: 4206 (estimated)
残杀威安全信息
[ 符号 ]:
GHS06, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H300 + H330-H311-H410
[ 警示性声明 ]:
Missing Phrase - N15.00950417-P260-P280-P302 + P352 + P312-P304 + P340 + P310-P403 + P233
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R25;R50/53
[ 安全声明 (欧洲) ]:
37-45-60-61-62
[ 危险品运输编码 ]:
UN 2811/2588
[ RTECS号 ]:
FC3150000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2922499912
残杀威合成路线
残杀威上下游产品
残杀威上游产品
残杀威下游产品
残杀威制备
1.将邻异丙基酚溶解在脱水二噁烷中，滴加甲基异氰酸酯和三乙胺，反应混合液逐渐升温。冷却，析出结晶，加石油醚后，结晶完全析出，收集结晶生成物，即残杀威，副产物尿素用石油英和水洗涤，除去溶剂，在50℃减压干燥，从苯中重结晶，得回收残杀威。原料消耗定额：邻异丙基酚890kg/t、甲基异氰酸酯330kg/t、脱水二噁烷150kg/t、石油醚500kg/t。
2.氯甲酸酯法
先合成异丙氧基氯甲酸酚酯，再胺解合成残杀威。两步反应均在低温下进行。
残杀威海关
[ 海关编码 ]: 2924199090
[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 包装
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
残杀威文献
Parasit. Vectors 7 , 577, (2015)
Phlebotomus papatasi vectors zoonotic cutaneous leishmaniasis. Previous expression of recombinant P. papatasi acetylcholinesterase (PpAChE1) revealed 85% amino acid sequence identity to mosquito AChE ...
Development of a multi-residue method in a fetal matrix: analysis of meconium.Anal. Bioanal. Chem 406(30) , 7785-97, (2014)
Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method ...
Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats.Bioanalysis 4(24) , 2897-907, (2012)
NMR combined with pattern recognition was recently introduced as a new technique for rapid xenobiotic toxicity evaluation. In this article, metabolic changes in the biofluid of rats after 90-day oral ...
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：残杀威标准溶液
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥138.0/1ml
联系人：刘佳
产品详情：残杀威标准溶液
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Propoxur
公司名：上海脉铂医药科技有限公司
区域：上海市嘉定区
价格：
￥1470.0/100mg
￥389.0/25mg
￥747.0/50mg
￥需询单/1g
联系人：李先生
产品详情：Propoxur
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥308.9/1ml
￥205.9/1ml
￥308.9/250mg
￥98.9/1ml
联系人：阿拉丁
产品详情：残杀威
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相关化合物
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