米贝拉地尔
米贝拉地尔用途
米贝拉地尔名称
[ CAS 号 ]:
116666-63-8
[ 中文名 ]:
米贝拉地尔
[ 英文名 ]:
Mibefradil dihydrochloride
[英文别名 ]:
- Mibefradil hydrochloride
- Mibefradil (dihydrochloride)
米贝拉地尔生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
IC50: 2.7 μM (T-type calcium channel), 18.6 μM (L-type calcium channel)[1]
[体外研究]
[体内研究]
[动物实验]
[参考文献]
[相关活性小分子]
米贝拉地尔物理化学性质
[ 沸点 ]:
647.6ºC at 760mmHg
[ 分子式 ]:
C29H40Cl2FN3O3
[ 分子量 ]:
568.551
[ 闪点 ]:
345.5ºC
[ 精确质量 ]:
567.243103
[ PSA ]:
67.45000
[ LogP ]:
6.87490
[ 蒸汽压 ]:
1.17E-16mmHg at 25°C
[ 储存条件 ]:
2-8℃
米贝拉地尔MSDS
米贝拉地尔毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AI8977250
- CHEMICAL NAME :
- Acetic acid, methyl-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)eth yl)-6-fluoro- 1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride, (1S-cis)-
- CAS REGISTRY NUMBER :
- 116666-63-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C29-H38-F-N3-O3.2Cl-H
- MOLECULAR WEIGHT :
- 568.62
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,4,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,4,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,4,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,4,1991 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 270 mg/kg
- SEX/DURATION :
- female 10-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- REFERENCE :
- REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 11,207,1997
米贝拉地尔安全信息
[ WGK德国 ]:
3
[ RTECS号 ]:
AI8977250
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥1686.0/10mg
¥1009.0/5mg
¥7443.0/50mg
¥需询单/1g
联系人:李先生
产品详情:Mibefradil dihydrochloride
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥522.9/5mg
¥2088.9/25mg
¥需询单/1g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:盐酸米贝拉地尔
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥804.0/5mg
¥1484.0/10mg
¥1663.06/10mg
¥999.6/5mg
联系人:夏言
产品详情:[Perfemiker]Mibefradil dihydrochloride,≥99%
公司名:上海陌孚医药科技有限公司
区域:上海市嘉定区
价格:
¥1496.75/10mg
¥6574.43/50mg
¥899.64/5mg
联系人:朱经理
产品详情:Mibefradil dihydrochloride
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相关化合物
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