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S-甲基-L-半胱氨酸

S-甲基-L-半胱氨酸用途

S-Methyl-L-cysteine 是一种天然产物,同时为催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A (MSRA) 的作用底物,具有抗氧化、神经保护及减肥的功效。

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S-甲基-L-半胱氨酸名称

[ CAS 号 ]:
1187-84-4

[ 中文名 ]:
S-甲基-L-半胱氨酸

[ 英文名 ]:
S-Methyl-L-cysteine

[中文别名 ]:

S-甲基-DL-半胱氨酸

[英文别名 ]:

L-methylcysteine
(2R)-2-(Methylamino)-3-sulfanylpropanoic acid
S-METHYL-CYSTEINE
H-Cys(Me)-OH
SMC
Methylcysteine
DL-S-Methyl-cysteine
N-Methyl-L-cystein
Cysteine, N-methyl, L-
(R)-N-Methylcysteine

S-甲基-L-半胱氨酸生物活性

[ 描述 ]:

S-Methyl-L-cysteine 是一种天然产物,同时为催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A (MSRA) 的作用底物,具有抗氧化、神经保护及减肥的功效。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[体内研究]

S-甲基-L-半胱氨酸(100 mg/kg)导致血浆葡萄糖,胰岛素,肿瘤坏死因子-α,胰岛素抵抗和改善抗氧化酶活性的显着减弱[1]。

[参考文献]

[1]. Thomas S, et al. Effect of s-methyl-L-cysteine on oxidative stress, inflammation and insulin resistance in male wistar rats fed with high fructose diet. Iran J Med Sci. 2015 Jan;40(1):45-50.

[相关活性小分子]

S-甲基-L-半胱氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
242.8±30.0 °C at 760 mmHg

[ 熔点 ]:
~240 °C (dec.)

[ 分子式 ]:
C₄H₉NO₂S

[ 分子量 ]:
135.185

[ 闪点 ]:
100.7±24.6 °C

[ 精确质量 ]:
135.035400

[ PSA ]:
88.62000

[ LogP ]:
0.47

[ 外观性状 ]:
淡米色

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.509

[ 储存条件 ]:
-20°C

S-甲基-L-半胱氨酸MSDS

详细MSDS(安全技术说明书)

S-甲基-L-半胱氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25-S36/37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

S-甲基-L-半胱氨酸合成路线

详细合成路线

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S-甲基-L-半胱氨酸文献

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.

PLoS ONE 10 , e0127063, (2015)

Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a downstream effector and...

Cysteine amide adduct formation from carboxylic acid drugs via UGT-mediated bioactivation in human liver microsomes.

Pharmazie 70 , 678-83, (2015)

Although chemical trapping has been widely used to evaluate cytochrome P450-mediated drug bioactivation, thus far, only a few in vitro-trapping studies have been performed on UDP-glucuronosyltransfera...

Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Bioorg. Med. Chem. Lett. 17 , 3921-4, (2007)

Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors...

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