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(R)-(+)-1,2-二硫戊环基-3-戊酸

(R)-(+)-1,2-二硫戊环基-3-戊酸用途

Lipoic acid ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。(R)-(+)-α-Lipoic acid 比外消旋 Lipoic acid 更有效。

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(R)-(+)-1,2-二硫戊环基-3-戊酸名称

[ CAS 号 ]:
1200-22-2

[ 中文名 ]:
(R)-(+)-1,2-二硫戊环基-3-戊酸

[ 英文名 ]:
lipoic acid

[中文别名 ]:

[英文别名 ]:

Thioctic acid
MFCD01631142
(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid
DL-Thioctic acid
(R)-(+)-1,2-Dithiolane-3-pentanoic acid
5-(1,2-Dithiolan-3-yl)pentanoic acid
(R)-1,2-Dithiolane-3-valeric Acid
(R)-Alpha-Lipoic Acid
1,2-Dithiolane-3-pentanoic acid
5-[(3R)-dithiolan-3-yl]pentanoic acid

(R)-(+)-1,2-二硫戊环基-3-戊酸生物活性

[ 描述 ]:

Lipoic acid ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。(R)-(+)-α-Lipoic acid 比外消旋 Lipoic acid 更有效。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢

天然产物 >> 酸和醛

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

硫辛酸((R)-(+)-α-硫辛酸)是在人体内生物合成的形式,其对于有氧代谢是必需的。硫辛酸((R)-(+)-α-硫辛酸)由于其在代谢中的“维生素样”作用而是营养和治疗上优选的形式。硫辛酸((R)-(+)-α-硫辛酸)和S -(-)-α-硫辛酸)构成外消旋混合物硫辛酸。只有硫辛酸((R)-(+)-α-硫辛酸)存在于自然界中,并且是四种线粒体酶复合物的必需辅助因子。已经提出硫辛酸((R)-(+)-α-硫辛酸)在营养和治疗上优选形成抗氧化剂[1]。

[参考文献]

[1]. Nasole E, et al. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.

[相关活性小分子]

(R)-(+)-1,2-二硫戊环基-3-戊酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
362.5±11.0 °C at 760 mmHg

[ 熔点 ]:
46-49ºC

[ 分子式 ]:
C₈H₁₄O₂S₂

[ 分子量 ]:
206.326

[ 闪点 ]:
173.0±19.3 °C

[ 精确质量 ]:
206.043518

[ PSA ]:
87.90000

[ LogP ]:
2.16

[ 外观性状 ]:
黄色结晶固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
水溶性：不溶

(R)-(+)-1,2-二硫戊环基-3-戊酸MSDS

详细MSDS(安全技术说明书)

(R)-(+)-1,2-二硫戊环基-3-戊酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

(R)-(+)-1,2-二硫戊环基-3-戊酸合成路线

详细合成路线

(R)-(+)-1,2-二硫戊环基-3-戊酸上下游产品

(R)-(+)-1,2-二硫戊环基-3-戊酸上游产品

(R)-(+)-1,2-二硫戊环基-3-戊酸下游产品

(R)-(+)-1,2-二硫戊环基-3-戊酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(R)-(+)-1,2-二硫戊环基-3-戊酸文献

2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.

Bioorg. Med. Chem. 15 , 6027-36, (2007)

2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological syste...

Synthesis and antioxidant properties of new chromone derivatives.

Bioorg. Med. Chem. 17 , 7218-26, (2009)

Nowadays, the recognition of the benefits of antioxidants is eliciting an increasingly interest in the search for new molecules with improved activity. The aim of the present work was to search for im...

Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.

J. Med. Chem. 54 , 2512-6, (2011)

A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates...

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