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Deltorphin 2

Deltorphin 2用途

Deltorphin 2 是一种选择性的 δ 阿片受体肽激动剂。

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Deltorphin 2名称

[ CAS 号 ]:
122752-16-3

[ 中文名 ]:
Deltorphin 2

[ 英文名 ]:
[D-Ala2] -Deltorphin II

[英文别名 ]:

Tyr-D-Ala-Phe-Glu-Val-Val-Gly amide
M.W. 782.89 C38H54N8O10
DELTORPHIN B
DADELT II
H-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2
H2N-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2
deltorphin II
TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2
DELTORPHIN II
Deltorphin 2

Deltorphin 2生物活性

[ 描述 ]:

Deltorphin 2 是一种选择性的 δ 阿片受体肽激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 神经疾病

多肽产品

[ 靶点 ]

δ opioid receptor[1]

[体外研究]

Deltorphin 2([D-Ala2] -Deltorphin II)是酶稳定的两栖七肽,对δ-阿片受体具有高亲和力和选择性。 Deltorphin 2是最具选择性的天然δ阿片受体激动剂[1]。

[参考文献]

[1]. Thomas SA, et al. Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J Pharmacol Exp Ther. 1997 May;281(2):817-25.

[相关活性小分子]

Deltorphin 2物理化学性质

[ 密度 ]:
1.272 g/cm3

[ 沸点 ]:
1256.2ºC at 760 mmHg

[ 分子式 ]:
C₃₈H₅₄N₈O₁₀

[ 分子量 ]:
782.88300

[ 闪点 ]:
713.5ºC

[ 精确质量 ]:
782.39600

[ PSA ]:
301.24000

[ LogP ]:
2.47290

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.575

[ 储存条件 ]:
-20°C

Deltorphin 2MSDS

详细MSDS(安全技术说明书)

Deltorphin 2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Deltorphin 2文献

Membrane partitioning of various delta-opioid receptor forms before and after agonist activations: the effect of cholesterol.

Biochim. Biophys. Acta 1778(6) , 1483-92, (2008)

Lipid rafts depicted as densely packed and thicker membrane microdomains, based on the dynamic clustering of cholesterol and sphingolipids, may help as platforms involved in a wide variety of cellular...

Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.

Eur. J. Neurosci. 32(11) , 1921-9, (2010)

We have shown that delta opioid receptor (DOPR)-mediated analgesia was enhanced in the complete Freund's adjuvant (CFA) model of inflammation. This effect is thought to originate from translocation of...

Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.

Pharm. Res. 26(5) , 1226-35, (2009)

To investigate whether conjunctival epithelial cells express transport processes for opioid peptides.We monitored the uptake of [(3)H]deltorphin II and [(3)H]DADLE, two hydrolysis-resistant synthetic ...

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