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5-氯-8-羟基喹啉

5-氯-8-羟基喹啉用途

Cloxiquine是一种抗菌,抗真菌,抗衰老和抗结核药物。

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5-氯-8-羟基喹啉名称

[ CAS 号 ]:
130-16-5

[ 中文名 ]:
5-氯-8-羟基喹啉

[ 英文名 ]:
5-Chloro-8-hydroxyquinoline

[中文别名 ]:

[英文别名 ]:

5-Chloro-8-hydroxy quinoline
5-chloroquinolin-8-ol
5-Chloroquinophenol
cloxiquine
5-Chlorooxine
EINECS 204-978-1
5-Chloro-8-quinolinol
5-Chloro-8-hydroxyquinoline
5-Chloro-quinolin-8-ol
8-Quinolinol, 5-chloro-

5-氯-8-羟基喹啉生物活性

[ 描述 ]:

Cloxiquine是一种抗菌,抗真菌,抗衰老和抗结核药物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[相关活性小分子]

5-氯-8-羟基喹啉物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
348.7±22.0 °C at 760 mmHg

[ 熔点 ]:
122-124 °C(lit.)

[ 分子式 ]:
C₉H₆ClNO

[ 分子量 ]:
179.603

[ 闪点 ]:
164.7±22.3 °C

[ 精确质量 ]:
179.013794

[ PSA ]:
33.12000

[ LogP ]:
3.02

[ 外观性状 ]:
淡黄色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.697

[ 储存条件 ]:
室温

5-氯-8-羟基喹啉MSDS

5-氯-8-羟基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC4590000

CHEMICAL NAME :: 8-Quinolinol, 5-chloro-

CAS REGISTRY NUMBER :: 130-16-5

BEILSTEIN REFERENCE NO. :: 0005289

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H6-Cl-N-O

MOLECULAR WEIGHT :: 179.61

WISWESSER LINE NOTATION :: T66 BNJ GG JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 1 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994

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5-氯-8-羟基喹啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VC4590000

[ 海关编码 ]:
2933499090

5-氯-8-羟基喹啉合成路线

5-氯-8-羟基喹啉上下游产品

5-氯-8-羟基喹啉上游产品

5-氯-8-羟基喹啉下游产品

5-氯-8-羟基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氯-8-羟基喹啉文献

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Photoluminescence and thermoanalytical studies of complexes based on 5-Cl-8-hydroxyquinoline and calix[4]arene ligands.

Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4) , 2213-20, (2013)

A innovative 5-Cl-8-oxyquinolinepropoxycalix[4]arene ligand (2) have been prepared, exhibiting, at room temperature, blue fluorescent light emission and resulting in shift band to green fluorescent li...

Poly(L-lactide) and poly(butylene succinate) immiscible blends: from electrospinning to biologically active materials.

Mater. Sci. Eng. C. Mater. Biol. Appl. 41 , 119-26, (2014)

For the first time the preparation of defect-free fibers from immiscible blends of high molar mass poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) in the whole range of the polyester weight...

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