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青霉素V钾

青霉素V钾用途

Penicillin V钾盐是一种抗生素, 用于治疗多种细菌感染, 是一种口服类的青霉素。

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青霉素V钾名称

[ CAS 号 ]:
132-98-9

[ 中文名 ]:
青霉素V钾

[ 英文名 ]:
Penicillin V potassium

[中文别名 ]:

[英文别名 ]:

D-a-Phenoxymethylpenicillinate K Salt
EINECS 205-086-5
Penicillin V potassium
MFCD00051771
Penicillin V Potassium Salt
Phenoxymethylpenicillin Potassium
pen-oral
Penicillin V (Potassium)

青霉素V钾生物活性

[ 描述 ]:

Penicillin V钾盐是一种抗生素, 用于治疗多种细菌感染, 是一种口服类的青霉素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

天然产物 >> 其他

研究领域 >> 感染

[相关活性小分子]

青霉素V钾物理化学性质

[ 密度 ]:
1.40

[ 沸点 ]:
681.4ºC at 760 mmHg

[ 熔点 ]:
197-202°C

[ 分子式 ]:
C₁₆H₁₇KN₂O₅S

[ 分子量 ]:
388.480

[ 闪点 ]:
365.9ºC

[ 精确质量 ]:
388.049530

[ PSA ]:
124.07000

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
1.69E-19mmHg at 25°C

[ 储存条件 ]:
2-8°C

青霉素V钾毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH9275000

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenoxy- acetamido)-, monopotassium salt

CAS REGISTRY NUMBER :: 132-98-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C16-H17-N2-O5-S.K

MOLECULAR WEIGHT :: 388.51

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMV1OR& F1 F1 GVQ &-KA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1040 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1124 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1351 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 195 gm/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16250 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-336,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82270 No. of Facilities: 1844 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82270 No. of Facilities: 301 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 6483 (estimated) No. of Female Employees: 3052 (estimated)

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青霉素V钾安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H334

[ 警示性声明 ]:
P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R42/43

[ 安全声明 (欧洲) ]:
S22-S26-S36/37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XH9275000

[ 海关编码 ]:
2941109400

青霉素V钾合成路线

详细合成路线

青霉素V钾上下游产品

青霉素V钾上游产品

青霉素V钾下游产品

青霉素V钾海关

[ 海关编码 ]: 2941109400

青霉素V钾文献

Fast determination of antibiotics in whole blood.

Clin. Microbiol. Infect. 19(9) , 869-74, (2013)

There is a need for analytical methods capable of monitoring blood antibiotic levels in real time. Here we present a method for quantifying antibiotic levels in whole blood that does not require any s...

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