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硫酸卷曲霉素

硫酸卷曲霉素用途

Capreomycin是多肽类抗生素,与其它抗生素结合用于MDR-肺结核。

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硫酸卷曲霉素名称

[ CAS 号 ]:
1405-37-4

[ 中文名 ]:
硫酸卷曲霉素

[ 英文名 ]:
Capreomycin Sulfate

[中文别名 ]:

[英文别名 ]:

EINECS 215-776-8
Capastat sulfate
MFCD00079032
Capreomycin (sulfate)

硫酸卷曲霉素生物活性

[ 描述 ]:

Capreomycin是多肽类抗生素,与其它抗生素结合用于MDR-肺结核。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Johansen SK, et al. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Mol Cell. 2006 Jul 21;23(2):173-82.

[相关活性小分子]

硫酸卷曲霉素物理化学性质

[ 沸点 ]:
1376.7ºC at 760mmHg

[ 分子式 ]:
C₂₅H₄₆N₁₄O₁₁S

[ 分子量 ]:
750.78

[ 闪点 ]:
786.4ºC

[ PSA ]:
458.90000

[ 外观性状 ]:
白色到灰白色固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: soluble50mg/mL | Freely soluble in water

硫酸卷曲霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX8930000

CHEMICAL NAME :: Capreomycin, sulfate (salt)

CAS REGISTRY NUMBER :: 1405-37-4

LAST UPDATED :: 199504

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1191 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 514 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,175,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,259,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5273 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 307 (estimated) No. of Female Employees: 251 (estimated)

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硫酸卷曲霉素安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312 + H332-H360

[ 警示性声明 ]:
P201-P261-P280-P301 + P312 + P330-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R61

[ 安全声明 (欧洲) ]:
53-22-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EX8930000

硫酸卷曲霉素文献

Antibiotic Susceptibility Patterns of Mycobacterium tuberculosis Isolates from Guizhou Province of China Against 13 Antituberculosis Drugs.

Microb. Drug Resist. 21 , 292-6, (2015)

A total of 92 Mycobacterium tuberculosis isolates were collected from patients with pulmonary tuberculosis (TB) in the Zunyi region between 2011 and 2012. Collected isolates were used to determine ant...

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

Antimicrob. Agents Chemother. 55 , 4712 - 4717, (2011)

Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both ...

Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis.

Antimicrob. Agents Chemother. 49 , 571-577, (2005)

Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resista...

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