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短杆菌肽

短杆菌肽用途

Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。

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短杆菌肽名称

[ CAS 号 ]:
1405-97-6

[ 中文名 ]:
短杆菌肽

[ 英文名 ]:
Gramicidin TFA

[英文别名 ]:

GRAMICIDIN (gramicidin A shown)
GRAMICIDINE
GRAMICIDIN

短杆菌肽生物活性

[ 描述 ]:

Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[ 靶点 ]

Bacterial[1]

[体外研究]

短杆菌肽是一种抗菌肽,作为膜中的通道组装并增加其对阳离子的渗透性。对于大肠杆菌和酿酒酵母的短杆菌素活性较差,如通过一系列短杆菌肽浓度的微生物存活率(％)所示,与短杆菌肽对金黄色葡萄球菌的作用形成对比。杀微生物活性发生在一系列低浓度的短杆菌肽和DODAB浓度下,对酿酒酵母无毒[1]。

[细胞实验]

将微生物和分散体混合并相互作用1小时，然后稀释至20,000倍，每次一式三份地接种0.1mL，并孵育（37℃下24小时）用于CFU计数。将作为平均值±标准偏差的细胞存活率（％）对DODAB和/或短杆菌肽浓度作图。作为不存在DODAB或DODAB /短杆菌肽分散体时细胞活力的对照，将标准细菌悬浮液加入到0.264M D-葡萄糖溶液中，稀释并在琼脂平板上铺展[1]。

[参考文献]

[1]. Ragioto DA, et al. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. Int J Nanomedicine. 2014 Jun 30;9:3183-92.

[相关活性小分子]

短杆菌肽物理化学性质

[ 熔点 ]:
229-230℃

[ 分子式 ]:
C₉₉H₁₄₀N₂₀O₁₇

[ 分子量 ]:
1882.29000

[ 精确质量 ]:
1881.07000

[ PSA ]:
548.99000

[ LogP ]:
11.26260

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol | Soluble in acetic acid and lower alcohols. Practically insoluble in water.

短杆菌肽MSDS

详细MSDS(安全技术说明书)

短杆菌肽安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21-36/37/38

[ 安全声明 (欧洲) ]:
26-36-24/25-22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MD8225000

短杆菌肽文献

Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen

FEBS Lett. 588(9) , 1590-5, (2014)

• Unsaturated lipids protect gramicidin channels from photosensitized inactivation. • Photosensitizer binding to membrane is independent of lipid unsaturation. • Double bonds in lipids reduce gramicid...

The contribution of raised intraneuronal chloride to epileptic network activity.

J. Neurosci. 35 , 7715-26, (2015)

Altered inhibitory function is an important facet of epileptic pathology. A key concept is that GABAergic activity can become excitatory if intraneuronal chloride rises. However, it has proved difficu...

Inversion of membrane surface charge by trivalent cations probed with a cation-selective channel.

Langmuir 28(45) , 15824-30, (2012)

We demonstrate that the cation-selective channel formed by gramicidin A can be used as a reliable sensor for studying the multivalent ion accumulation at the surfaces of charged lipid membranes and th...

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