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Stattic

Stattic用途

Stattic 是一种有效的 STAT3 抑制剂，常用于癌症治疗。

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Stattic名称

[ CAS 号 ]:
19983-44-9

[ 中文名 ]:
6-硝基-1H-1lambda~6~-苯并[b]噻吩-1,1-二酮

[ 英文名 ]:
Stattic

[中文别名 ]:

盐酸萘替芬

[英文别名 ]:

6-Nitro-benzo<b>thiophen-1,1-dioxid
6-nitro-benzo[b]thiophene-1,1-dioxide
Benzo[b]thiophene, 6-nitro-, 1,1-dioxide
6-nitro-1H-1λ-benzo[b]thiophene-1,1-dione
6-nitro-1
STAT3 Inhibitor V,Stattic
Benzo[b]thiophene,6-nitro-,1,1-dioxide
6-Nitro-1-benzothiophene 1,1-dioxide
6-nitro-1-benzothiophene-1,1-dioxide
Stattic

Stattic生物活性

[ 描述 ]:

Stattic是有效的 STAT3 活化和二聚化的抑制剂。

[ 相关类别 ]:

信号通路 >> JAK/STAT信号通路 >> STAT

信号通路 >> 干细胞及 Wnt 通路 >> STAT

研究领域 >> 癌症

[ 靶点 ]

STAT3

[体外研究]

Stattic在较高浓度(20μM)下抑制Panc-1和HPAC胰腺癌细胞系的ALDH +和D44 +/CD24 +亚群中的STAT3磷酸化(Y705)。 Stattic选择性抑制P-STAT3,如Panc-1和HPAC的ALDH +和CD44 +/CD24 +亚群中P-ERK1/2的抑制缺乏所证明。抑制STAT3下游靶标的ALDH +和CD44 +/CD24 +胰腺癌细胞亚群[1]。 Stattic可降低LPS诱导的ICAM-1和VCAM-1表达以及STAT3磷酸化[2]。

[细胞实验]

将胰腺癌干细胞样细胞（在96孔板中3,000 /孔）与所需浓度的化合物一式三份在37℃下孵育72小时。进行MTT活力测定，并在595nm处读取吸光度。

[参考文献]

[1]. Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.

[2]. Cho YS, et al. Inhibition of STAT3 phosphorylation by sulforaphane reduces adhesion molecule expression in vascular endothelial cell. Can J Physiol Pharmacol. 2015 Nov 18:1-7.

[相关活性小分子]

Stattic物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
461.1±45.0 °C at 760 mmHg

[ 熔点 ]:
184ºC

[ 分子式 ]:
C₈H₅NO₄S

[ 分子量 ]:
211.195

[ 闪点 ]:
232.6±28.7 °C

[ 精确质量 ]:
210.993927

[ PSA ]:
88.34000

[ LogP ]:
1.31

[ 外观性状 ]:
white to beige

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
Store at +4°C

[ 水溶解性 ]:
DMSO: >20mg/mL

StatticMSDS

详细MSDS(安全技术说明书)

Stattic安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

Stattic合成路线

详细合成路线

Stattic上下游产品

Stattic上游产品

Stattic下游产品

Stattic海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Stattic文献

6-Mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1.

Inflamm. Bowel Dis. 20(9) , 1487-95, (2014)

Inflammatory bowel disease is characterized by chronic intestinal inflammation. Azathioprine and its metabolite 6-mercaptopurine (6-MP) are effective immunosuppressive drugs that are widely used in pa...

Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway.

Hum. Pathol. 46(2) , 284-94, (2015)

It is hypothesized that cigarette smoke may increase MMP2 and MMP9 secretion through Jak/Stat pathway in the aorta, thereby facilitating abdominal aortic aneurysm (AAA) formation/progression in smoker...

Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling.

Oncotarget 6 , 16422-36, (2015)

The role and underlying mechanism of Raf kinase inhibitory protein (RKIP) in nasopharyngeal carcinoma (NPC) metastasis remain unclear. Here, we showed that RKIP was downregulated in the NPC with high ...

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