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氯苯吩嗪

氯苯吩嗪用途

Clofazimine是一种脂溶性亚氨基酚嗪类染料, 具有显著的抗炎效果, 与其它抗分支杆菌药物联用来AIDS和克罗恩病。

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氯苯吩嗪名称

[ CAS 号 ]:
2030-63-9

[ 中文名 ]:
氯苯吩嗪

[ 英文名 ]:
Clofazimine

[中文别名 ]:

[英文别名 ]:

Clofaziminum [INN-Latin]
Clofazimine
Clofaziminum
Chlofazimine
Clofazimina [INN-Spanish]
Lamprene
Lampren
B 663 (Pharmaceutical)
Clofazimina

氯苯吩嗪生物活性

[ 描述 ]:

Clofazimine是一种脂溶性亚氨基酚嗪类染料, 具有显著的抗炎效果, 与其它抗分支杆菌药物联用来AIDS和克罗恩病。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

染料试剂

研究领域 >> 炎症/免疫

[相关活性小分子]

氯苯吩嗪物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
566.9±50.0 °C at 760 mmHg

[ 熔点 ]:
210-212°

[ 分子式 ]:
C₂₇H₂₂Cl₂N₄

[ 分子量 ]:
473.396

[ 闪点 ]:
296.7±30.1 °C

[ 精确质量 ]:
472.122162

[ PSA ]:
42.21000

[ LogP ]:
7.26

[ 外观性状 ]:
固体;Yellow to Amber to Dark red powder to crystal

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
Practically insoluble in water, soluble in methylene chloride, very slightly soluble in ethanol (96 per cent). It shows polymorphism (5.9).

氯苯吩嗪MSDS

详细MSDS(安全技术说明书)

氯苯吩嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1578000

CHEMICAL NAME :: Phenazine, 2,10-dihydro-3-(p-chloroanilino)-10-(p-chlorophenyl)- 2-(isopropylimino)-

CAS REGISTRY NUMBER :: 2030-63-9

BEILSTEIN REFERENCE NO. :: 0060420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C27-H22-Cl2-N4

MOLECULAR WEIGHT :: 473.43

WISWESSER LINE NOTATION :: T C666 BN IN EHJ BR DG& ENUY1&1 FMR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,911,1994

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氯苯吩嗪安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SG1578000

[ 海关编码 ]:
35040000

氯苯吩嗪上下游产品

氯苯吩嗪上游产品

氯苯吩嗪下游产品

氯苯吩嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氯苯吩嗪文献

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...

Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.

Proc. Natl. Acad. Sci. U. S. A. 112(3) , 869-74, (2015)

A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB)....

Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation.

Drug Deliv Transl Res 5 , 257-67, (2015)

Contemporary chemotherapy is limited by disseminated, resistant cancer. Targeting nanoparticulate drug delivery systems that encapsulate synergistic drug combinations are a rational means to increase ...

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